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Greater muscle damage in athletes with ACTN3 R577X (RS1815739) gene polymorphism after an ultra-endurance race: a pilot study

Biology of sport, 2017-01, Vol.34 (2), p.105-110 [Peer Reviewed Journal]

Copyright © Biology of Sport 2017 2017 ;ISSN: 0860-021X ;EISSN: 2083-1862 ;DOI: 10.5114/biolsport.2017.64583 ;PMID: 28566803

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  • Title:
    Greater muscle damage in athletes with ACTN3 R577X (RS1815739) gene polymorphism after an ultra-endurance race: a pilot study
  • Author: Belli, T ; Crisp, A H ; Verlengia, R
  • Subjects: ACTN3 ; Adventure race ; Genetics ; Muscle damage ; Original Paper ; Ultra-endurance
  • Is Part Of: Biology of sport, 2017-01, Vol.34 (2), p.105-110
  • Description: In this study, we aimed to investigate the influence of gene polymorphism on muscle damage responses in athletes competing in an ultra-endurance race. Twenty moderate to well-trained ultra-runners who had entered in an official 37.1 km adventure race (22.1 km mountain biking, 10.9 km trekking, 4.1 km water trekking, 30 m rope course, and orienteering) volunteered for the study. Blood samples were collected for genotyping and analysis of muscle protein levels before and after the race. Percentage changes (pre- to post-race) of serum myoglobin [XX = 5,377% vs. RX/RR = 1,666%; = 0.005, effect size (ES) = 1.73], creatine kinase (XX = 836.5% vs. RX/RR = 455%; = 0.04, ES = 1.29), lactate dehydrogenase (XX = 82% vs. RX/RR = 65%; = 0.002, ES = 1.61), and aspartate aminotransferase (XX = 148% vs. RX/RR = 75%; = 0.02, ES = 1.77) were significantly greater for XX than RX/RR genotypes. ES analysis confirmed a large magnitude of muscle damage in XX genotype ultra-runners. Therefore, athletes with the genotype experienced more muscle damage after an adventure race. This suggests that ultra-runners with alpha-actinin-3 deficiency may be more susceptible to rhabdomyolysis and associated health complications during ultra-endurance competitions.
  • Publisher: Poland: Institute of Sport in Warsaw
  • Language: English
  • Identifier: ISSN: 0860-021X
    EISSN: 2083-1862
    DOI: 10.5114/biolsport.2017.64583
    PMID: 28566803
  • Source: AUTh Library subscriptions: ProQuest Central
    PubMed Central
    Alma/SFX Local Collection
    DOAJ Directory of Open Access Journals
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