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A 10-year Isfahan cohort on cardiovascular disease as a master plan for a multi-generation non-communicable disease longitudinal study: methodology and challenges

Journal of human hypertension, 2019-11, Vol.33 (11), p.807-816 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Nov 2019 ;ISSN: 0950-9240 ;EISSN: 1476-5527 ;DOI: 10.1038/s41371-018-0126-2 ;PMID: 30385824

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Title:
A 10-year Isfahan cohort on cardiovascular disease as a master plan for a multi-generation non-communicable disease longitudinal study: methodology and challenges
Author: Sarrafzadegan, Nizal ; Hassannejad, Razieh ; Roohafza, Hamidreza ; Sadeghi, Masoumeh ; Talaei, Mohammad ; Oveisgharan, Shahram ; Mansourian, Marjan
Subjects: Aged ; Analysis ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - mortality ; Children ; Communicable diseases ; Diabetes mellitus ; Epigenesis, Genetic ; Epigenetics ; Female ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Health risk assessment ; Health Status ; Heredity ; Humans ; Incidence ; Iran - epidemiology ; Life Style ; Longitudinal Studies ; Male ; Medical research ; Medicine, Experimental ; Methods ; Middle Aged ; Noncommunicable Diseases - epidemiology ; Noncommunicable Diseases - mortality ; Pedigree ; Phenotype ; Population studies ; Prognosis ; Research Design ; Risk Assessment ; Risk Factors ; Time Factors
Is Part Of: Journal of human hypertension, 2019-11, Vol.33 (11), p.807-816
Description: A 10-year longitudinal population-based study entitled Isfahan Cohort Study (ICS) was conducted in 2001-2011 with cardiovascular disease (CVD) as the primary outcome. We considered ICS as a master plan for a multi-level non-communicable disease (NCD) study named Isfahan Cohort Study 2 (ICS2). ICS2 is a multi-generation 10-year cohort study with new goals and outcomes that have been started in 2013, recruiting a sub-sample of ICS (n = 1487) and a new recruited sample (n = 1355) aged 35 years and over, all living in urban and rural areas of two counties in central Iran. In addition, 2500 of participant's adult children were selected randomly, as well as 1000 of their grandchildren. The aim of ICS2 is to detect the incidence of some NCDs including CVD, cancers, and diabetes and to identify the impact of their behavioral, metabolic, environmental, and genetic risk factors. In addition, studying lifestyle behaviors in three generations in a hierarchical manner of parents, their children and grandchildren in ICS2 will improve our knowledge on other determinants such as epigenetics of NCDs.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0950-9240
EISSN: 1476-5527
DOI: 10.1038/s41371-018-0126-2
PMID: 30385824
Source: MEDLINE
ProQuest Central

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A 10-year Isfahan cohort on cardiovascular disease as a master plan for a multi-generation non-communicable disease longitudinal study: methodology and challenges

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Nov 2019 ;ISSN: 0950-9240 ;EISSN: 1476-5527 ;DOI: 10.1038/s41371-018-0126-2 ;PMID: 30385824

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