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Metabolomic correlates of aerobic capacity among elderly adults

Clinical cardiology (Mahwah, N.J.), 2018-10, Vol.41 (10), p.1300-1307 [Peer Reviewed Journal]

2018 Wiley Periodicals, Inc. ;ISSN: 0160-9289 ;EISSN: 1932-8737 ;DOI: 10.1002/clc.23016 ;PMID: 30350416

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Title:
Metabolomic correlates of aerobic capacity among elderly adults
Author: Koh, Angela S. ; Gao, Fei ; Tan, Ru S. ; Zhong, Liang ; Leng, Shuang ; Zhao, Xiaodan ; Fridianto, Kevin T. ; Ching, Jianhong ; Lee, Si Y. ; Keng, Bryan M. H. ; Yeo, Tee Joo ; Tan, Shu Y. ; Tan, Hong C. ; Lim, Chin T. ; Koh, Woon‐Puay ; Kovalik, Jean‐Paul
Subjects: aerobic capacity ; Age Distribution ; Age Factors ; Aged ; aging ; cardiovascular ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - physiopathology ; Cause of Death - trends ; Clinical Investigations ; elderly ; Exercise - physiology ; Exercise Test ; Exercise Tolerance - physiology ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Metabolism ; metabolomics ; Metabolomics - methods ; Oxygen - metabolism ; Oxygen Consumption - physiology ; Physical fitness ; Prognosis ; Prospective Studies ; Singapore - epidemiology ; Survival Rate - trends
Is Part Of: Clinical cardiology (Mahwah, N.J.), 2018-10, Vol.41 (10), p.1300-1307
Description: Background Aerobic capacity is a powerful predictor of cardiovascular disease and all‐cause mortality, and it declines with advancing age. Hypothesis Since physical activity alters body metabolism, metabolism markers will likely differ between subjects with high vs low aerobic capacities. Methods Community‐based participants without physician‐diagnosed heart disease, stroke or cancer underwent same‐day multimodal assessment of cardiovascular function (by echocardiography and magnetic resonance feature tracking of left atrium) and aerobic capacity by peak oxygen uptake (VO2) metrics. Associations between VO2 and cardiovascular and metabolomics profiles were studied in adjusted models including standard covariates. Results We studied 141 participants, of whom 82 (58.2%) had low VO2, while 59 (41.8%) had high VO2. Compared to participants with high VO2, participants with low VO2 had more adverse cardiovascular parameters, such as lower ratio of peak velocity flow in early diastole to peak velocity flow in late diastole by atrial contraction of >0.8 (76% vs 35%, adjusted odd ratio [OR] = 4.1, 95% confidence interval [CI] [1.7‐9.5], P = 0.001) and lower left atrial conduit strain (11.3 ± 4.0 vs 15.6 ± 6.1%, adjusted OR = 1.1, 95% CI [1.002‐1.3], P = 0.045). High VO2 was associated with lower accumulation of wide‐spectrum acyl‐carnitines (OR = 0.6, 95% CI [0.4‐0.9], P = 0.013), alanine (OR = 0.1, 95% CI [0.01‐0.9], P = 0.044) and glutamine /glutamate (OR = 0.1, 95% CI [0.01‐0.5], P = 0.007), compared to low VO2. Conclusion Elderly adults with low VO2 have adverse cardiovascular and metabolic parameters compared to their counterparts with high VO2. Combined cardiac and metabolomics phenotyping may be a promising tool to provide insights into physiological states, useful for tracking future interventions related to physical activity among community cohorts.
Publisher: New York: Wiley Periodicals, Inc
Language: English
Identifier: ISSN: 0160-9289
EISSN: 1932-8737
DOI: 10.1002/clc.23016
PMID: 30350416
Source: MEDLINE
PubMed Central

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Metabolomic correlates of aerobic capacity among elderly adults

2018 Wiley Periodicals, Inc. ;ISSN: 0160-9289 ;EISSN: 1932-8737 ;DOI: 10.1002/clc.23016 ;PMID: 30350416

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