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Prognostic Significance of Ambulatory BP Monitoring in CKD: A Report from the Chronic Renal Insufficiency Cohort (CRIC) Study

Journal of the American Society of Nephrology, 2020-11, Vol.31 (11), p.2609-2621 [Peer Reviewed Journal]

Copyright © 2020 by the American Society of Nephrology. ;Copyright © 2020 by the American Society of Nephrology 2020 ;ISSN: 1046-6673 ;EISSN: 1533-3450 ;DOI: 10.1681/ASN.2020030236 ;PMID: 32973085

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Title:
Prognostic Significance of Ambulatory BP Monitoring in CKD: A Report from the Chronic Renal Insufficiency Cohort (CRIC) Study
Author: Rahman, Mahboob ; Wang, Xue ; Bundy, Joshua D ; Charleston, Jeanne ; Cohen, Debbie ; Cohen, Jordana ; Drawz, Paul E ; Ghazi, Lama ; Horowitz, Edward ; Lash, James P ; Schrauben, Sarah ; Weir, Matthew R ; Xie, Dawei ; Townsend, Raymond R
Subjects: Aged ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Cardiovascular Diseases - epidemiology ; Circadian Rhythm ; Clinical Epidemiology ; Disease Progression ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Male ; Masked Hypertension - epidemiology ; Masked Hypertension - physiopathology ; Middle Aged ; Mortality ; Prognosis ; Prospective Studies ; Renal Insufficiency, Chronic - physiopathology ; Systole ; White Coat Hypertension - epidemiology ; White Coat Hypertension - physiopathology
Is Part Of: Journal of the American Society of Nephrology, 2020-11, Vol.31 (11), p.2609-2621
Description: Whether ambulatory BP monitoring is of value in evaluating risk for outcomes in patients with CKD is not clear. We followed 1502 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study for a mean of 6.72 years. We evaluated, as exposures, ambulatory BP monitoring profiles (masked uncontrolled hypertension, white-coat effect, sustained hypertension, and controlled BP), mean ambulatory BP monitoring and clinic BPs, and diurnal variation in BP-reverse dipper (higher at nighttime), nondipper, and dipper (lower at nighttime). Outcomes included cardiovascular disease (a composite of myocardial infarction, cerebrovascular accident, heart failure, and peripheral arterial disease), kidney disease (a composite of ESKD or halving of the eGFR), and mortality. Compared with having controlled BP, the presence of masked uncontrolled hypertension independently associated with higher risk of the cardiovascular outcome and the kidney outcome, but not with all-cause mortality. Higher mean 24-hour systolic BP associated with higher risk of cardiovascular outcome, kidney outcome, and mortality, independent of clinic BP. Participants with the reverse-dipper profile of diurnal BP variation were at higher risk of the kidney outcome. In this cohort of participants with CKD, BP metrics derived from ambulatory BP monitoring are associated with cardiovascular outcomes, kidney outcomes, and mortality, independent of clinic BP. Masked uncontrolled hypertension and mean 24-hour BP associated with high risk of cardiovascular disease and progression of kidney disease. Alterations of diurnal variation in BP are associated with high risk of progression of kidney disease, stroke, and peripheral arterial disease. These data support the wider use of ambulatory BP monitoring in the evaluation of hypertension in patients with CKD. This article contains a podcast at https://www.asn-online.org/media/podcast/JASN/2020_09_24_JASN2020030236.mp3.
Publisher: United States: American Society of Nephrology
Language: English
Identifier: ISSN: 1046-6673
EISSN: 1533-3450
DOI: 10.1681/ASN.2020030236
PMID: 32973085
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection

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Prognostic Significance of Ambulatory BP Monitoring in CKD: A Report from the Chronic Renal Insufficiency Cohort (CRIC) Study

Copyright © 2020 by the American Society of Nephrology. ;Copyright © 2020 by the American Society of Nephrology 2020 ;ISSN: 1046-6673 ;EISSN: 1533-3450 ;DOI: 10.1681/ASN.2020030236 ;PMID: 32973085

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