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High Blood Pressure and Cardiovascular Disease
Hypertension (Dallas, Tex. 1979), 2020-02, Vol.75 (2), p.285-292
[Peer Reviewed Journal]
2020 American Heart Association, Inc ;ISSN: 0194-911X ;EISSN: 1524-4563 ;DOI: 10.1161/HYPERTENSIONAHA.119.14240 ;PMID: 31865786
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Title:
High Blood Pressure and Cardiovascular Disease
Author:
Fuchs, Flávio D
;
Whelton, Paul K
Subjects:
Aging - physiology
;
Cardiovascular Diseases - epidemiology
;
Cardiovascular Diseases - prevention & control
;
Causality
;
Humans
;
Hypertension - epidemiology
;
Hypertension - physiopathology
;
Hypertension - therapy
;
Preventive Health Services
;
Public Health
;
Risk Factors
Is Part Of:
Hypertension (Dallas, Tex. 1979), 2020-02, Vol.75 (2), p.285-292
Description:
Fragmented investigation has masked the overall picture for causes of cardiovascular disease (CVD). Among the risk factors for CVD, high blood pressure (BP) is associated with the strongest evidence for causation and it has a high prevalence of exposure. Biologically, normal levels of BP are considerably lower than what has typically been characterized as normal in research and clinical practice. We propose that CVD is primarily caused by a right-sided shift in the population distribution of BP. Our view that BP is the predominant risk factor for CVD is based on conceptual postulates that have been tested in observational investigations and clinical trials. Large cohort studies have demonstrated that high BP is an important risk factor for heart failure, atrial fibrillation, chronic kidney disease, heart valve diseases, aortic syndromes, and dementia, in addition to coronary heart disease and stroke. In multivariate modeling, the presumed attributable risk of high BP for stroke and coronary heart disease has increased steadily with progressive use of lower values for normal BP. Meta-analysis of BP-lowering randomized controlled trials has demonstrated a benefit which is almost identical to that predicted from BP risk relationships in cohort studies. Prevention of age-related increases in BP would, in large part, reduce the vascular consequences usually attributed to aging, and together with intensive treatment of established hypertension would eliminate a large proportion of the population burden of BP-related CVD.
Publisher:
United States: American Heart Association, Inc
Language:
English
Identifier:
ISSN: 0194-911X
EISSN: 1524-4563
DOI: 10.1161/HYPERTENSIONAHA.119.14240
PMID: 31865786
Source:
GFMER Free Medical Journals
MEDLINE
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