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COVID-19 and Cardiovascular Disease: From Bench to Bedside
Circulation research, 2021-04, Vol.128 (8), p.1214-1236
[Peer Reviewed Journal]
2021 American Heart Association, Inc. 2021 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.121.317997 ;PMID: 33856918
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Title:
COVID-19 and Cardiovascular Disease: From Bench to Bedside
Author:
Chung, Mina K
;
Zidar, David A
;
Bristow, Michael R
;
Cameron, Scott J
;
Chan, Timothy
;
Harding, 3rd, Clifford V
;
Kwon, Deborah H
;
Singh, Tamanna
;
Tilton, John C
;
Tsai, Emily J
;
Tucker, Nathan R
;
Barnard, John
;
Loscalzo, Joseph
Subjects:
Angiotensin-Converting Enzyme 2 - metabolism
;
Biomarkers - metabolism
;
Cardiomyopathies - virology
;
Cardiovascular Diseases - virology
;
COVID-19 - complications
;
COVID-19 - epidemiology
;
COVID-19 - therapy
;
COVID-19 - virology
;
Gene Expression
;
Humans
;
Immune System - physiology
;
Myocardium - enzymology
;
Myocytes, Cardiac - enzymology
;
Myocytes, Cardiac - virology
;
Neuropilin-1 - metabolism
;
Platelet Activation
;
Renin-Angiotensin System - physiology
;
Return to Sport
;
Review
;
Risk Factors
;
RNA, Messenger - metabolism
;
SARS-CoV-2 - physiology
;
SARS-CoV-2 - ultrastructure
;
Spike Glycoprotein, Coronavirus - metabolism
;
Troponin - metabolism
;
Ventricular Remodeling
;
Virus Attachment
;
Virus Internalization - drug effects
Is Part Of:
Circulation research, 2021-04, Vol.128 (8), p.1214-1236
Description:
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.
Publisher:
United States: Lippincott Williams & Wilkins
Language:
English
Identifier:
ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.121.317997
PMID: 33856918
Source:
Freely Accessible Journals
MEDLINE
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