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Risk factors for cardiovascular disease in HIV/AIDS patients treated with highly active antiretroviral therapy (HAART) in the central-southern region of the state of Paraná - Brazil

Ciência & saude coletiva, 2019-05, Vol.24 (5), p.1903-1914 [Peer Reviewed Journal]

Copyright © 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/deed.en (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 1413-8123 ;ISSN: 1678-4561 ;EISSN: 1678-4561 ;DOI: 10.1590/1413-81232018245.16682017 ;PMID: 31166523

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  • Title:
    Risk factors for cardiovascular disease in HIV/AIDS patients treated with highly active antiretroviral therapy (HAART) in the central-southern region of the state of Paraná - Brazil
  • Author: Muller, Erildo Vicente ; Gimeno, Suely Godoy Agostinho
  • Subjects: Acquired immune deficiency syndrome ; AIDS ; Antiretroviral drugs ; Cardiovascular disease ; Drug therapy ; Health Policy & Services ; HIV ; Human immunodeficiency virus ; Risk analysis ; Risk factors ; Side effects
  • Is Part Of: Ciência & saude coletiva, 2019-05, Vol.24 (5), p.1903-1914
  • Description: The aim of this study was to describe metabolic changes in HIV/AIDS patients according to the treatment regimen. It was a retrospective cohort conducted from 2002 to 2014. Researchers surveyed clinical variables and treatment regimen of 538 individuals. They used measures of central tendency and marginal logistic regression to determine the influence of the treatment regimen on clinical variables over time; survival was estimated using Kaplan-Meier curves. 56.2% of patients were male, 82.2% white, 33.8% had 4 to 7 years of study, 49.2% were married, 98.5% had sexual transmission, and 89.0% were heterosexuals. During the study period, 24.4% had hypertension, 18.2% changed cholesterol, 39.7% low HDL, 51.3% high triglycerides and 33.3% hyperglycemia. Treatment regimens with nucleotide reverse transcriptase inhibitors associated with protease inhibitors, and the association of different classes of antiretrovirals have been associated with greater lipid changes. Higher metabolic changes were observed in patients with longer treatment time. It is concluded that preventive measures, as well as early treatment, can contribute to minimize the risks of developing cardiovascular diseases.
  • Publisher: Brazil: Associação Brasileira de Saúde Coletiva
  • Language: English;Portuguese
  • Identifier: ISSN: 1413-8123
    ISSN: 1678-4561
    EISSN: 1678-4561
    DOI: 10.1590/1413-81232018245.16682017
    PMID: 31166523
  • Source: SciELO
    AUTh Library subscriptions: ProQuest Central
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