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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

Molecular cell, 2015-06, Vol.58 (5), p.870-885 [Peer Reviewed Journal]

2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;ISSN: 1097-2765 ;ISSN: 1097-4164 ;EISSN: 1097-4164 ;DOI: 10.1016/j.molcel.2015.03.027 ;PMID: 25921068

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Title:
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Author: Rybak-Wolf, Agnieszka ; Stottmeister, Christin ; Glažar, Petar ; Jens, Marvin ; Pino, Natalia ; Giusti, Sebastian ; Hanan, Mor ; Behm, Mikaela ; Bartok, Osnat ; Ashwal-Fluss, Reut ; Herzog, Margareta ; Schreyer, Luisa ; Papavasileiou, Panagiotis ; Ivanov, Andranik ; Öhman, Marie ; Refojo, Damian ; Kadener, Sebastian ; Rajewsky, Nikolaus
Subjects: Animals ; Base Sequence ; Brain - metabolism ; Cell Line ; Drosophila melanogaster ; Humans ; Mice ; Molecular Biology ; Molecular Sequence Data ; molekylärbiologi ; Neurogenesis ; Organ Specificity ; RNA - genetics ; RNA - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Analysis, DNA ; Synapses - metabolism
Is Part Of: Molecular cell, 2015-06, Vol.58 (5), p.870-885
Description: Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers. [Display omitted] •circRNAs are highly abundant in the mammalian brain and enriched in synaptoneurosomes•circRNAs are upregulated during neuronal differentiation•Many circRNAs show dynamic expression, independent of linear transcript dynamics•Neuronal circRNAs are significantly conserved in expression and sequence Rybak-Wolf et al. combined computation and experiment to compile a catalog of circRNA expression in the brain. circRNAs are highly enriched in the mammalian brain, with specific and dynamic expression during neuronal differentiation, often independent of linear transcripts. Brain-expressed circRNAs are often conserved in expression and display elevated sequence conservation.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1097-2765
ISSN: 1097-4164
EISSN: 1097-4164
DOI: 10.1016/j.molcel.2015.03.027
PMID: 25921068
Source: Cell Press Free Archives
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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;ISSN: 1097-2765 ;ISSN: 1097-4164 ;EISSN: 1097-4164 ;DOI: 10.1016/j.molcel.2015.03.027 ;PMID: 25921068

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