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Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel

Journal of the American College of Cardiology, 2019-07, Vol.74 (2), p.238-256 [Peer Reviewed Journal]

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. ;2019. The Authors ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.05.024 ;PMID: 31296297

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Title:
Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel
Author: Ibanez, Borja ; Aletras, Anthony H ; Arai, Andrew E ; Arheden, Hakan ; Bax, Jeroen ; Berry, Colin ; Bucciarelli-Ducci, Chiara ; Croisille, Pierre ; Dall'Armellina, Erica ; Dharmakumar, Rohan ; Eitel, Ingo ; Fernández-Jiménez, Rodrigo ; Friedrich, Matthias G ; García-Dorado, David ; Hausenloy, Derek J ; Kim, Raymond J ; Kozerke, Sebastian ; Kramer, Christopher M ; Salerno, Michael ; Sánchez-González, Javier ; Sanz, Javier ; Fuster, Valentin
Subjects: area at risk ; Biomedical Research ; Cardiac and Cardiovascular Systems ; Cardiac Imaging Techniques ; Cardiomyocytes ; Clinical Medicine ; clinical trial ; Clinical trials ; Clinical Trials as Topic ; Edema ; endpoint ; Engineering and Technology ; Fibrosis ; Heart ; Heart - diagnostic imaging ; Heart attacks ; Hemorrhage ; Heterogeneity ; Humans ; infarct size ; Ischemia ; Kardiologi ; Klinisk medicin ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical and Health Sciences ; Medical Engineering ; Medical Laboratory and Measurements Technologies ; Medical research ; Medicin och hälsovetenskap ; Medicinsk laboratorie- och mätteknik ; Medicinteknik ; Microvasculature ; Myocardial infarction ; Myocardial Infarction - surgery ; Myocardial Reperfusion ; Necrosis ; Postoperative Period ; Standardization ; STEMI ; Teknik
Is Part Of: Journal of the American College of Cardiology, 2019-07, Vol.74 (2), p.238-256
Description: After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes.
Publisher: United States: Elsevier Limited
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2019.05.024
PMID: 31296297
Source: GFMER Free Medical Journals
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Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. ;2019. The Authors ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.05.024 ;PMID: 31296297

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