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Transcatheter Aortic Valve Replacement 2016: A Modern-Day "Through the Looking-Glass" Adventure

Journal of the American College of Cardiology, 2016-03, Vol.67 (12), p.1472-1487 [Peer Reviewed Journal]

Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Mar 29, 2016 ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2015.12.059 ;PMID: 27012409

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  • Title:
    Transcatheter Aortic Valve Replacement 2016: A Modern-Day "Through the Looking-Glass" Adventure
  • Author: Vahl, Torsten P ; Kodali, Susheel K ; Leon, Martin B
  • Subjects: Adventure ; Aortic Valve Stenosis - surgery ; Catheters ; Clinical trials ; Heart ; Heart Valve Prosthesis ; Humans ; Medicine ; Mortality ; Patient Selection ; Risk Factors ; Studies ; Surgery ; Transcatheter Aortic Valve Replacement - trends
  • Is Part Of: Journal of the American College of Cardiology, 2016-03, Vol.67 (12), p.1472-1487
  • Description: Transcatheter aortic valve replacement (TAVR) has become a safe and effective therapy for patients with severe aortic stenosis (AS). In recent trials, the hemodynamic performance and clinical outcomes of the latest generation of TAVR devices demonstrated at least parity with surgical outcomes in patients of similar risk. Many initial obstacles with TAVR have largely been overcome, including frequent access site complications and concerns about strokes and paravalvular leaks. Using a multidisciplinary heart team approach, patient selection, procedural planning, and device implantation have been refined and optimized such that clinical outcomes are generally predictable and reproducible. Future research will focus on the durability of TAVR devices, further enhancements in clinical outcomes, and adjunctive therapies. On the basis of initial results from ongoing clinical trials, the indication for TAVR will likely expand to lower-risk patients. This review provides an overview of recent progress in this field, and highlights future opportunities and directions.
  • Publisher: United States: Elsevier Limited
  • Language: English
  • Identifier: ISSN: 0735-1097
    EISSN: 1558-3597
    DOI: 10.1016/j.jacc.2015.12.059
    PMID: 27012409
  • Source: GFMER Free Medical Journals
    MEDLINE
    Alma/SFX Local Collection
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