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Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2: a randomized study

International journal of cancer, 2021-06, Vol.148 (12), p.3051 [Peer Reviewed Journal]

ISSN: 0020-7136 ;ISSN: 1097-0215 ;EISSN: 1097-0215 ;DOI: 10.1002/ijc.33482

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  • Title:
    Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2: a randomized study
  • Author: Aarnio, Riina ; Isacson, Isabella ; Sanner, Karin ; Gustavsson, Inger M. ; Gyllensten, Ulf B. ; Olovsson, Matts
  • Subjects: HPV test ; Obstetrics and Gynaecology ; Obstetrik och gynekologi ; Primary cervical screening ; Self-sampling
  • Is Part Of: International journal of cancer, 2021-06, Vol.148 (12), p.3051
  • Description: Primary screening with human papillomavirus (HPV) test is more effective in reducing cervical cancer incidence than cytology and it also offers the opportunity to self-sample. We conducted a randomized study to compare vaginal self-sampling with cervical sampling by medical professionals for HPV testing concerning prevalence of HPV and detection of cervical intraepithelial neoplasia (CIN) of grade 2 or worse (CIN2+) or grade 3 or worse (CIN3+) in primary screening. In total, 11 951 women aged 30-60 years were randomized into two groups, 5961 for self-sampling (SS arm) and 5990 for sampling by medical professionals (SMP arm). Sampling was performed with a RoversViba-brush in the SS arm and a cytobrush in the SMP arm. All samples were applied to an indicating FTA elute card and analyzed for HPV using a clinically validated real-time PCR test (hpVIR). All HPV-positive women performed repeated sampling about 6 months later using the same procedure as used initially. All HPV-positive women in the second sampling were referred to colposcopy. The prevalence of HPV in the first test did not differ between the SS arm (6.8%, 167/2466) and the SMP arm (7.8%, 118/1519) ( P = .255). The prevalence of CIN2+ per 1000 screened women was 17 (43/2466 × 1000) (95%CI 13-24) in the SS arm and 21 (32/1519 × 1000) (95%CI 15-30) in the SMP arm. For CIN3+, the prevalence per 1000 screened women was 14 (35/2466 × 1000) (95%CI 10-20) in the SS arm and 15 (23/1519 × 1000) (95%CI 10-23) in the SMP arm. In conclusion, self-sampling and sampling by medical professionals showed the same prevalence of HPV and detection rate of CIN2+ and CIN3+ in histology.
  • Language: English
  • Identifier: ISSN: 0020-7136
    ISSN: 1097-0215
    EISSN: 1097-0215
    DOI: 10.1002/ijc.33482
  • Source: SWEPUB Freely available online
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