Language:

Mitochondrial fission augments capsaicin-induced axonal degeneration

Acta neuropathologica, 2015-01, Vol.129 (1), p.81-96 [Peer Reviewed Journal]

The Author(s) 2014 ;COPYRIGHT 2015 Springer ;Springer-Verlag Berlin Heidelberg 2015 ;ISSN: 0001-6322 ;EISSN: 1432-0533 ;DOI: 10.1007/s00401-014-1354-3 ;PMID: 25322817

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Mitochondrial fission augments capsaicin-induced axonal degeneration
Author: Chiang, Hao ; Ohno, Nobuhiko ; Hsieh, Yu-Lin ; Mahad, Don J. ; Kikuchi, Shin ; Komuro, Hitoshi ; Hsieh, Sung-Tsang ; Trapp, Bruce D.
Subjects: Animals ; Axons - drug effects ; Axons - pathology ; Axons - physiology ; Calcium - metabolism ; Capsaicin ; Capsaicin - toxicity ; Cells, Cultured ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - pathology ; Ganglia, Spinal - physiology ; Male ; Medicine ; Medicine & Public Health ; Membrane Potential, Mitochondrial - drug effects ; Membrane Potential, Mitochondrial - physiology ; Mice, Inbred ICR ; Mitochondria - drug effects ; Mitochondria - pathology ; Mitochondria - physiology ; Mitochondrial DNA ; Mitochondrial Dynamics - drug effects ; Mitochondrial Dynamics - physiology ; Nerve Degeneration - chemically induced ; Nerve Degeneration - pathology ; Nerve Degeneration - physiopathology ; Neurosciences ; Original Paper ; Pathology ; Phenols (Class of compounds) ; Physiological aspects ; Rats, Sprague-Dawley ; TRPV Cation Channels - metabolism
Is Part Of: Acta neuropathologica, 2015-01, Vol.129 (1), p.81-96
Description: Capsaicin, an agonist of transient receptor potential vanilloid receptor 1, induces axonal degeneration of peripheral sensory nerves and is commonly used to treat painful sensory neuropathies. In this study, we investigated the role of mitochondrial dynamics in capsaicin-induced axonal degeneration. In capsaicin-treated rodent sensory axons, axonal swellings, decreased mitochondrial stationary site length and reduced mitochondrial transport preceded axonal degeneration. Increased axoplasmic Ca 2+ mediated the alterations in mitochondrial length and transport. While sustaining mitochondrial transport did not reduce axonal swellings in capsaicin-treated axons, preventing mitochondrial fission by overexpression of mutant dynamin-related protein 1 increased mitochondrial length, retained mitochondrial membrane potentials and reduced axonal loss upon capsaicin treatment. These results establish that mitochondrial stationary site size significantly affects axonal integrity and suggest that inhibition of Ca 2+ -dependent mitochondrial fission facilitates mitochondrial function and axonal survival following activation of axonal cationic channels.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0001-6322
EISSN: 1432-0533
DOI: 10.1007/s00401-014-1354-3
PMID: 25322817
Source: ProQuest One Psychology
SpringerOpen
AUTh Library subscriptions: ProQuest Central
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Mitochondrial fission augments capsaicin-induced axonal degeneration

The Author(s) 2014 ;COPYRIGHT 2015 Springer ;Springer-Verlag Berlin Heidelberg 2015 ;ISSN: 0001-6322 ;EISSN: 1432-0533 ;DOI: 10.1007/s00401-014-1354-3 ;PMID: 25322817

Searching Remote Databases, Please Wait