Language:

Beyond Diagnostic Accuracy: The Clinical Utility of Diagnostic Tests

Clinical chemistry (Baltimore, Md.), 2012-12, Vol.58 (12), p.1636-1643 [Peer Reviewed Journal]

2014 INIST-CNRS ;2012 American Association for Clinical Chemistry ;COPYRIGHT 2012 American Association for Clinical Chemistry, Inc. ;Copyright American Association for Clinical Chemistry Dec 2012 ;ISSN: 0009-9147 ;EISSN: 1530-8561 ;DOI: 10.1373/clinchem.2012.182576 ;PMID: 22730450 ;CODEN: CLCHAU

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Beyond Diagnostic Accuracy: The Clinical Utility of Diagnostic Tests
Author: BOSSUYT, Patrick M. M ; REITSMA, Johannes B ; LINNET, Kristian ; MOONS, Karel G. M
Subjects: Accuracy ; Accuracy and precision ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Biomarkers - analysis ; Clinical Laboratory Techniques - statistics & numerical data ; Clinical trials ; Decision making ; Expected utility ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical research ; Medical sciences ; Medicine, Experimental ; Molecular biophysics ; Mortality ; Outcome Assessment (Health Care) ; Patients ; Randomized Controlled Trials as Topic ; Reproducibility of Results ; Research Design
Is Part Of: Clinical chemistry (Baltimore, Md.), 2012-12, Vol.58 (12), p.1636-1643
Description: Like any other medical technology or intervention, diagnostic tests should be thoroughly evaluated before their introduction into daily practice. Increasingly, decision makers, physicians, and other users of diagnostic tests request more than simple measures of a test's analytical or technical performance and diagnostic accuracy; they would also like to see testing lead to health benefits. In this last article of our series, we introduce the notion of clinical utility, which expresses--preferably in a quantitative form--to what extent diagnostic testing improves health outcomes relative to the current best alternative, which could be some other form of testing or no testing at all. In most cases, diagnostic tests improve patient outcomes by providing information that can be used to identify patients who will benefit from helpful downstream management actions, such as effective treatment in individuals with positive test results and no treatment for those with negative results. We describe how comparative randomized clinical trials can be used to estimate clinical utility. We contrast the definition of clinical utility with that of the personal utility of tests and markers. We show how diagnostic accuracy can be linked to clinical utility through an appropriate definition of the target condition in diagnostic-accuracy studies.
Publisher: Washington, DC: American Association for Clinical Chemistry
Language: English
Identifier: ISSN: 0009-9147
EISSN: 1530-8561
DOI: 10.1373/clinchem.2012.182576
PMID: 22730450
CODEN: CLCHAU
Source: AUTh Library subscriptions: ProQuest Central
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Beyond Diagnostic Accuracy: The Clinical Utility of Diagnostic Tests

2014 INIST-CNRS ;2012 American Association for Clinical Chemistry ;COPYRIGHT 2012 American Association for Clinical Chemistry, Inc. ;Copyright American Association for Clinical Chemistry Dec 2012 ;ISSN: 0009-9147 ;EISSN: 1530-8561 ;DOI: 10.1373/clinchem.2012.182576 ;PMID: 22730450 ;CODEN: CLCHAU

Searching Remote Databases, Please Wait