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Single-Cell Genomics

Clinical chemistry (Baltimore, Md.), 2019-08, Vol.65 (8), p.972-985 [Peer Reviewed Journal]

2019 American Association for Clinical Chemistry. ;COPYRIGHT 2019 American Association for Clinical Chemistry, Inc. ;Copyright American Association for Clinical Chemistry Aug 2019 ;ISSN: 0009-9147 ;EISSN: 1530-8561 ;DOI: 10.1373/clinchem.2017.283895 ;PMID: 30872376

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Title:
Single-Cell Genomics
Author: Paolillo, Carmela ; Londin, Eric ; Fortina, Paolo
Subjects: Alzheimers disease ; Antigens ; Biology ; Cancer ; Cell division ; Cell Separation - methods ; Deoxyribonucleic acid ; Developmental biology ; DNA ; Epigenomics ; Evolution ; Gene Amplification ; Gene sequencing ; Genomes ; Genomics ; Genomics - methods ; Heterogeneity ; History, 20th Century ; History, 21st Century ; Humans ; Immunity - genetics ; Medical research ; Medicine, Experimental ; Metastasis ; Microbiology ; Microbiota - genetics ; Neoplasms - genetics ; Nervous system ; Neurophysiology ; Neurosciences ; Reproducibility of Results ; Ribonucleic acid ; RNA ; RNA polymerase ; Sequence Analysis, RNA - methods ; Single-Cell Analysis - history ; Single-Cell Analysis - methods ; Single-Cell Analysis - trends ; Studies ; Systematic review ; Transcriptome - genetics ; Tumorigenesis ; Tumors
Is Part Of: Clinical chemistry (Baltimore, Md.), 2019-08, Vol.65 (8), p.972-985
Description: Single-cell genomics is an approach to investigate cell heterogeneity and to identify new molecular features correlated with clinical outcomes. This approach allows identification of the complexity of cell diversity in a sample without the loss of information that occurs when multicellular or bulk tissue samples are analyzed. The first single-cell RNA-sequencing study was published in 2009, and since then many more studies and single-cell sequencing methods have been published. These studies have had a major impact on several fields, including microbiology, neurobiology, cancer, and developmental biology. Recently, improvements in reliability and the development of commercial single-cell isolation platforms are opening the potential of this technology to the clinical laboratory. In this review we provide an overview of the current state of single-cell genomics. We describe opportunities in clinical research and medical applications.
Publisher: England: American Association for Clinical Chemistry, Inc
Language: English
Identifier: ISSN: 0009-9147
EISSN: 1530-8561
DOI: 10.1373/clinchem.2017.283895
PMID: 30872376
Source: MEDLINE
ProQuest Central

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Single-Cell Genomics

2019 American Association for Clinical Chemistry. ;COPYRIGHT 2019 American Association for Clinical Chemistry, Inc. ;Copyright American Association for Clinical Chemistry Aug 2019 ;ISSN: 0009-9147 ;EISSN: 1530-8561 ;DOI: 10.1373/clinchem.2017.283895 ;PMID: 30872376

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