Language:

Effect of Residual Bacteria on the Outcome of Pulp Regeneration In Vivo

Journal of dental research, 2017-01, Vol.96 (1), p.100-106 [Peer Reviewed Journal]

International & American Associations for Dental Research 2016 ;ISSN: 0022-0345 ;EISSN: 1544-0591 ;DOI: 10.1177/0022034516671499 ;PMID: 27694153

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Effect of Residual Bacteria on the Outcome of Pulp Regeneration In Vivo
Author: Verma, P. ; Nosrat, A. ; Kim, J.R. ; Price, J.B. ; Wang, P. ; Bair, E. ; Xu, H.H. ; Fouad, A.F.
Subjects: Animals ; Bacteria ; Blood clots ; Blood coagulation ; Bone Regeneration - physiology ; Canine teeth ; Dental pulp ; Dental Pulp - diagnostic imaging ; Dental Pulp - growth & development ; Dental Pulp - microbiology ; Dental Pulp Cavity - diagnostic imaging ; Dental Pulp Cavity - growth & development ; Dental Pulp Cavity - microbiology ; Dentin ; Dentistry ; Disinfection ; Dogs ; Ferrets ; Growth factors ; Hydrogels ; Male ; Mustela ; Radiography, Dental ; Regression analysis ; Root Canal Therapy - methods ; Sodium hypochlorite ; Stem Cell Transplantation - methods ; Stem cells ; Studies ; Teeth ; Tissue engineering ; Tissue Scaffolds - microbiology ; Treatment Outcome ; Umbilical cord
Is Part Of: Journal of dental research, 2017-01, Vol.96 (1), p.100-106
Description: It is not known to what extent residual infection may interfere with the success of pulp regeneration procedures. The aim of this study was to determine, radiographically and histologically, the effect of residual bacteria on the outcome of pulp regeneration mediated by a tissue-engineered construct as compared with traditional revascularization. Periapical lesions were induced in 24 canine teeth of 6 ferrets. After disinfection with 1.25% NaOCl and triple antibiotic paste, ferret dental pulp stem cells, encapsulated in a hydrogel scaffold, were injected into half the experimental teeth. The other half were treated with the traditional revascularization protocol with a blood clot scaffold. After 3 mo, block sections of the canine teeth were imaged radiographically and processed for histologic and histobacteriologic analyses. Associations between variables of interest were evaluated through mixed effects regression models. There were no significant differences between the 2 experimental groups in radiographic root development (P > 0.05). There was a significant association between the presence of persistent periapical radiolucency and root wall thickness (P = 0.02). There was also no significant difference in histologic findings between the 2 experimental groups (P > 0.05). The presence of residual bacteria was significantly associated with lack of radiographic growth (P < 0.001). The amount of dentin-associated mineralized tissue formed in teeth with residual bacteria was significantly less than in teeth with no residual bacteria (P < 0.001). Residual bacteria have a critical negative effect on the outcome of regenerative endodontic procedures.
Publisher: Los Angeles, CA: SAGE Publications
Language: English
Identifier: ISSN: 0022-0345
EISSN: 1544-0591
DOI: 10.1177/0022034516671499
PMID: 27694153
Source: MEDLINE
Alma/SFX Local Collection

Back to results list

Result 1 Next Go to Next page


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Effect of Residual Bacteria on the Outcome of Pulp Regeneration In Vivo

International & American Associations for Dental Research 2016 ;ISSN: 0022-0345 ;EISSN: 1544-0591 ;DOI: 10.1177/0022034516671499 ;PMID: 27694153

Searching Remote Databases, Please Wait