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Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas

Journal of cardiovascular electrophysiology, 2004-03, Vol.15 (3), p.349-355 [Peer Reviewed Journal]

ISSN: 1045-3873 ;EISSN: 1540-8167 ;DOI: 10.1046/j.1540-8167.2004.03487.x ;PMID: 15030427

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Title:
Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas
Author: Jongbloed, Monique R M ; Schalij, Martin J ; Poelmann, Robert E ; Blom, Nico A ; Fekkes, Madelon L ; Wang, Zhiyong ; Fishman, Glenn I ; Gittenberger-De Groot, Adriana C
Subjects: Animals ; Arrhythmias, Cardiac - embryology ; Arrhythmias, Cardiac - metabolism ; Arrhythmias, Cardiac - physiopathology ; beta-Galactosidase - metabolism ; Cardiovascular Physiological Phenomena ; Disease Models, Animal ; Embryonic and Fetal Development - physiology ; Fetal Heart - embryology ; Fetal Heart - growth & development ; Fetal Heart - metabolism ; Gestational Age ; Heart Atria - embryology ; Heart Atria - growth & development ; Heart Atria - metabolism ; Heart Conduction System - embryology ; Heart Conduction System - growth & development ; Heart Conduction System - metabolism ; Heart Ventricles - embryology ; Heart Ventricles - growth & development ; Heart Ventricles - metabolism ; Lac Operon - physiology ; Mice ; Models, Cardiovascular ; Myocardium - metabolism ; Statistics as Topic
Is Part Of: Journal of cardiovascular electrophysiology, 2004-03, Vol.15 (3), p.349-355
Description: The occurrence of arrhythmias in adult patients may arise preferentially in anatomic regions derived from the specialized cardiac conduction system. To examine this hypothesis, we performed a detailed analysis of the developing cardiac conduction system using the recently described CCS-lacZ transgenic mouse strain. Transgenic embryos (E9.5-15.5) were stained for beta-galactosidase activity and co-stained with the myocardial marker HHF35. Results were reconstructed three dimensionally. CCS-lacZ expression was observed in the sinoatrial node, left and right venous valves, septum spurium, right and left atrioventricular ring, His bundle, bundle branches, and right ventricular moderator band. Furthermore, lacZ-positive cells could be demonstrated for the first time in the left atrium, in the posterior wall surrounding the pulmonary venous orifice. and, in later stages, surrounding the pulmonary venous wall. These cells were continuous with the left venous valve in the right atrium. LacZ-positive tissue also could be identified in Bachmann's bundle, running retro-aortically between the right atrium and left atrium. Known arrhythmogenic areas including Bachmann's bundle, the pulmonary veins, and sinus venosus derived internodal structures, demonstrate lacZ expression. These data support the hypothesis that areas derived from the developing cardiac conduction system may contribute to the arrhythmogenic substrate in adult hearts.
Publisher: United States
Language: English
Identifier: ISSN: 1045-3873
EISSN: 1540-8167
DOI: 10.1046/j.1540-8167.2004.03487.x
PMID: 15030427
Source: MEDLINE
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Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas

ISSN: 1045-3873 ;EISSN: 1540-8167 ;DOI: 10.1046/j.1540-8167.2004.03487.x ;PMID: 15030427

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