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Polymer-free versus permanent polymer drug eluting stents in coronary artery disease: A meta-analysis of 10 RCTs with 6575 patients

慢性疾病与转化医学（英文）, 2015, Vol.1 (4) [Peer Reviewed Journal]

ISSN: 2095-882X ;EISSN: 2589-0514

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  • Title:
    Polymer-free versus permanent polymer drug eluting stents in coronary artery disease: A meta-analysis of 10 RCTs with 6575 patients
  • Author: De-Wei Wu Meng-Yue Yu Hai-Yang Gao Li Zhang Fei Song Xin-Yue Zhang Yong-Jian Wu
  • Is Part Of: 慢性疾病与转化医学（英文）, 2015, Vol.1 (4)
  • Description: Background:Permanent polymer drug eluting stents (PP-DES) may induce inflammation of the vessel wall due to the existence of the polymer,which may delay intimal healing.Polymer-free DES (PF-DES) that eliminate the polymeric carrier may potentially lead to safer DES.However,the safety and efficacy of PF-DES remains controversial.Methods:Randomized controlled trials comparing PF-DES with PP-DES were searched in online database including MEDLINE,Excerpta Medica Database (EMBASE) and Cochrane Library.Studies reporting late lumen loss (LLL),all-cause death,myocardial infarction (MI),target lesion revascularization (TLR) and late stent thrombosis (LST) were enrolled and quantitatively analyzed.Results:Ten studies enrolling 6575 patients were included in this meta-analysis.The PF-DES showed a benefit in reducing all-cause death (OR =0.77,95％ CI:0.61 to 0.98,P =0.03) and long-term LLL (weighted mean difference (WMD)-0.16 mm,95％ CI:-0.22 to -0.11 mm,P ＜ 0.001),while no superiority was found in reducing short-term LLL
  • Language: Chinese
  • Identifier: ISSN: 2095-882X
    EISSN: 2589-0514
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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