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Oxidized LDL, insulin resistance and central blood pressure after gestational diabetes mellitus

Acta obstetricia et gynecologica Scandinavica, 2016-12, Vol.95 (12), p.1425-1432 [Peer Reviewed Journal]

2016 Nordic Federation of Societies of Obstetrics and Gynecology ;2016 Nordic Federation of Societies of Obstetrics and Gynecology. ;Acta Obstetricia et Gynecologica Scandinavica © 2016 Nordic Federation of Societies of Obstetrics and Gynecology ;ISSN: 0001-6349 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.13029 ;PMID: 27682002 ;CODEN: AOGSAE

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Title:
Oxidized LDL, insulin resistance and central blood pressure after gestational diabetes mellitus
Author: Vilmi-Kerälä, Tiina ; Palomäki, Outi ; Kankkunen, Päivi ; Juurinen, Leena ; Uotila, Jukka ; Palomäki, Ari
Subjects: Adult ; Biomarkers - blood ; Blood Pressure ; Blood Pressure Determination ; Case-Control Studies ; Central blood pressure ; Diabetes, Gestational - blood ; Diabetes, Gestational - physiopathology ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; gestational diabetes mellitus ; homeostasis model assessment of insulin resistance ; Humans ; Insulin Resistance ; Linear Models ; Lipoproteins, LDL - blood ; Middle Aged ; obesity ; Obesity - blood ; Obesity - physiopathology ; oxidized low-density lipoprotein ; Pregnancy
Is Part Of: Acta obstetricia et gynecologica Scandinavica, 2016-12, Vol.95 (12), p.1425-1432
Description: Introduction Gestational diabetes mellitus (GDM) is an indicator of future cardiovascular disease. We investigated whether sensitive biomarkers of increased cardiovascular risk differ between women with and without a history of GDM few years after pregnancy, and whether obesity affects the results. Material and methods We studied two cohorts – 120 women with a history of GDM and 120 controls, on average 3.7 years after delivery. Circulating concentrations of oxidized low‐density lipoprotein (oxLDL) were determined by ELISA. The homeostasis model assessment of insulin resistance (HOMA‐IR) index was used to estimate insulin resistance. Central blood pressure (cBP) was measured noninvasively from a radial artery pulse wave. The primary outcomes were possible differences in oxLDL, HOMA‐IR or cBP between the groups. Secondly, we investigated the influence of obesity on the results, also using adjusted multiple linear regression analyses. Results OxLDL concentrations or cBP did not differ between the two cohorts, but HOMA‐IR was significantly higher in women with previous GDM than in controls, 1.3 ± 0.9 (SD) and 1.1 ± 0.9, respectively (p = 0.022). In subgroup analyses, HOMA‐IR (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) cBP were significantly higher in obese subgroups compared with non‐obese ones. Body mass index was an important determinant of HOMA‐IR and cBP in multiple linear regression analyses. Conclusions Over 3 years after delivery, women with GDM were still more insulin‐resistant than controls. Obesity turned out to be a more important determinant of insulin resistance and cBP compared with GDM.
Publisher: United States: Blackwell Publishing Ltd
Language: English;French;German
Identifier: ISSN: 0001-6349
EISSN: 1600-0412
DOI: 10.1111/aogs.13029
PMID: 27682002
CODEN: AOGSAE
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
Alma/SFX Local Collection

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Oxidized LDL, insulin resistance and central blood pressure after gestational diabetes mellitus

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