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5′-terminal Sequences and Coding Region of Late Simian Virus 40 mRNAs are Derived from Noncontiguous Segments of the Viral Genome

Proceedings of the National Academy of Sciences - PNAS, 1977-12, Vol.74 (12), p.5323-5327 [Peer Reviewed Journal]

ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.74.12.5323 ;PMID: 202950

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Title:
5′-terminal Sequences and Coding Region of Late Simian Virus 40 mRNAs are Derived from Noncontiguous Segments of the Viral Genome
Author: Lavi, Sara ; Groner, Yoram
Subjects: Base Sequence ; Chromosome Mapping ; DNA ; DNA mapping ; DNA, Viral - genetics ; Genetic hybridization ; Genomes ; Guanine Nucleotides - metabolism ; Messenger RNA ; Methylation ; Molecular Weight ; Molecules ; Nucleic Acid Hybridization ; Nucleotide sequences ; Nucleotides ; RNA ; RNA, Messenger - genetics ; RNA, Viral - genetics ; Simian virus 40 ; Simian virus 40 - genetics
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 1977-12, Vol.74 (12), p.5323-5327
Description: The region of the simian virus 40 genome complementary to the 5′end of the most abundant poly(A)-containing 19S and 16S mRNAs was mapped by hybridization of double-labeled RNA ([3H]methyl group and [14C]uridine) to specific DNA fragments. Chemical identification of methylated residues indicated that a common ``leader'' sequence adjacent to the 5′terminus of both 19S and 16S mRNA is transcribed from DNA sequences located between 0.67 and 0.76 map units. The estimated size of this ``leader'' RNA, which does not code for any known viral protein, is 170-200 nucleotides. Our results indicate that sequences complementary to the ``leader'' region and coding portion of 16S mRNA are located in separate parts of the simian virus 40 genome.
Publisher: United States: National Academy of Sciences of the United States of America
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.74.12.5323
PMID: 202950
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central

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5′-terminal Sequences and Coding Region of Late Simian Virus 40 mRNAs are Derived from Noncontiguous Segments of the Viral Genome

ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.74.12.5323 ;PMID: 202950

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