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Alzheimer's disease: risk factors and potentially protective measures

Journal of biomedical science, 2019-05, Vol.26 (1), p.33-33, Article 33 [Tạp chí có phản biện]

COPYRIGHT 2019 BioMed Central Ltd. ;2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s). 2019 ;ISSN: 1423-0127 ;ISSN: 1021-7770 ;EISSN: 1423-0127 ;DOI: 10.1186/s12929-019-0524-y ;PMID: 31072403

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Nhan đề:
Alzheimer's disease: risk factors and potentially protective measures
Tác giả: Silva, Marcos Vinícius Ferreira ; Loures, Cristina de Mello Gomide ; Alves, Luan Carlos Vieira ; de Souza, Leonardo Cruz ; Borges, Karina Braga Gomes ; Carvalho, Maria das Graças
Chủ đề: Acquired risk factors ; Alzheimer's disease ; Alzheimers disease ; Analysis ; Cerebrovascular diseases ; Clinical trials ; Cognition & reasoning ; Cognitive ability ; Cytoplasm ; Dementia ; Dementia disorders ; Diabetes mellitus ; Diagnosis ; Dyslipidemia ; Emotional behavior ; Genetic aspects ; Genetic risk factors ; Genetic susceptibility ; Genetics ; Health risk assessment ; Health risks ; Homeostasis ; Hormone replacement therapy ; Hypertension ; Memory ; Mental depression ; Neurofibrillary tangles ; Peptides ; Physical activity ; Physiology ; Plaques ; Prevention ; Proteins ; Review ; Risk analysis ; Risk assessment ; Risk factors ; Tau protein ; Vascular diseases ; Womens health ; β-Amyloid
Là 1 phần của: Journal of biomedical science, 2019-05, Vol.26 (1), p.33-33, Article 33
Mô tả: Alzheimer's disease (AD) is the most common type of dementia and typically manifests through a progressive loss of episodic memory and cognitive function, subsequently causing language and visuospatial skills deficiencies, which are often accompanied by behavioral disorders such as apathy, aggressiveness and depression. The presence of extracellular plaques of insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein (P-tau) in the neuronal cytoplasm is a remarkable pathophysiological cause in patients' brains. Approximately 70% of the risk of developing AD can be attributed to genetics. However, acquired factors such as cerebrovascular diseases, diabetes, hypertension, obesity and dyslipidemia increase the risk of AD development. The aim of the present minireview was to summarize the pathophysiological mechanism and the main risk factors for AD. As a complement, some protective factors associated with a lower risk of disease incidence, such as cognitive reserve, physical activity and diet will also be addressed.
Nơi xuất bản: England: BioMed Central Ltd
Ngôn ngữ: English
Số nhận dạng: ISSN: 1423-0127
ISSN: 1021-7770
EISSN: 1423-0127
DOI: 10.1186/s12929-019-0524-y
PMID: 31072403
Nguồn: Open Access: DOAJ Directory of Open Access Journals
Open Access: PubMed Central
SpringerOpen
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central

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Alzheimer's disease: risk factors and potentially protective measures

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