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Clinical Characteristics of Korean Patients with Elderly-Onset Crohn’s Disease: Results from the Prospective CONNECT Study

Gut and liver, 2022-11, Vol.16 (6), p.995 [Peer Reviewed Journal]

ISSN: 1976-2283 ;EISSN: 2005-1212

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  • Title:
    Clinical Characteristics of Korean Patients with Elderly-Onset Crohn’s Disease: Results from the Prospective CONNECT Study
  • Author: You Sun Kim ; Min Jeong Na ; Byong Duk Ye ; Jae Hee Cheon ; Jong Pil Im ; Joo Sung Kim
  • Subjects: Cohort studies ; Crohn disease ; Elderly-onset ; Prognosis
  • Is Part Of: Gut and liver, 2022-11, Vol.16 (6), p.995
  • Description: The clinical course and prognosis of patients with elderly-onset Crohn’s disease (CD) remain unclear. This study aimed to analyze the clinical characteristics and outcomes of elderly-onset CD patients from the prospective CONNECT study cohort, a nationwide, multicenter cohort study of patients with CD in Korea. Among a total of 1,175 patients in the prospective CONNECT study cohort, 94 patients (Montreal age A3) were included and divided into two groups according to their age at diagnosis: the elderly-onset group (diagnosed with CD after 60 years of age, n=26, 67.54±6.7 years) and late adult-onset group (diagnosed as CD at age 41 to 59 years, n=68, 48.06±5.1 years). The elderly-onset group was characterized by a lower Crohn’s disease activity index at diagnosis (124.89±101.9 vs 189.55±128.6, p=0.023) and higher rates of previous anti-tuberculosis treatment (34.6% vs 4.4%, p<0.001) than the late adult-onset group. Compared with the late adult-onset group, the elderly-onset group showed a significantly less use of thiopurines (p=0.003), as well as anti-tumor necrosis factor-alpha agents (p=0.047). Additionally, the elderly-onset group was less likely to require bowel resection than the late adult-onset group (p=0.067), suggesting that elderly-onset CD patients in Korea appear to have more favorable clinical outcomes than late adult-onset CD patients. (Gut Liver 2022;16:995-1000)
  • Publisher: 대한소화기내시경학회
  • Language: Korean
  • Identifier: ISSN: 1976-2283
    EISSN: 2005-1212
  • Source: PubMed Central
    KoreaMed Open Access
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