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The role of brain vasculature in neurodegenerative disorders

Nature neuroscience, 2018-10, Vol.21 (10), p.1318-1331 [Peer Reviewed Journal]

Copyright Nature Publishing Group Oct 2018 ;ISSN: 1097-6256 ;EISSN: 1546-1726 ;DOI: 10.1038/s41593-018-0234-x ;PMID: 30250261

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Title:
The role of brain vasculature in neurodegenerative disorders
Author: Sweeney, Melanie D ; Kisler, Kassandra ; Montagne, Axel ; Toga, Arthur W ; Zlokovic, Berislav V
Subjects: Amyotrophic lateral sclerosis ; Animal models ; Animals ; Biomarkers ; Blood flow ; Blood vessels ; Blood Vessels - pathology ; Blood Vessels - physiopathology ; Brain ; Brain - pathology ; Cerebral blood flow ; Disorders ; Humans ; Integrity ; Multiple sclerosis ; Neurodegeneration ; Neurodegenerative diseases ; Neurodegenerative Diseases - pathology ; Parkinson's disease ; Pathogenesis ; Structure-function relationships
Is Part Of: Nature neuroscience, 2018-10, Vol.21 (10), p.1318-1331
Description: Adequate supply of blood and structural and functional integrity of blood vessels are key to normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood-brain barrier dysfunction are early findings in neurodegenerative disorders in humans and animal models. Here we first examine molecular definition of cerebral blood vessels, as well as pathways regulating cerebral blood flow and blood-brain barrier integrity. Then we examine the role of cerebral blood flow and blood-brain barrier in the pathogenesis of Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. We focus on Alzheimer's disease as a platform of our analysis because more is known about neurovascular dysfunction in this disease than in other neurodegenerative disorders. Finally, we propose a hypothetical model of Alzheimer's disease biomarkers to include brain vasculature as a factor contributing to the disease onset and progression, and we suggest a common pathway linking brain vascular contributions to neurodegeneration in multiple neurodegenerative disorders.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1097-6256
EISSN: 1546-1726
DOI: 10.1038/s41593-018-0234-x
PMID: 30250261
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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The role of brain vasculature in neurodegenerative disorders

Copyright Nature Publishing Group Oct 2018 ;ISSN: 1097-6256 ;EISSN: 1546-1726 ;DOI: 10.1038/s41593-018-0234-x ;PMID: 30250261

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