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Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Anais da Academia Brasileira de Ciências, 2015-08, Vol.87 (2 Suppl), p.1397-1408 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ;ISSN: 0001-3765 ;ISSN: 1678-2690 ;EISSN: 1678-2690 ;DOI: 10.1590/0001-3765201520150056 ;PMID: 26247152

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Title:
Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil
Author: Silva, Gabriela L da ; Luft, Carolina ; Lunardelli, Adroaldo ; Amaral, Robson H ; Melo, Denizar A da Silva ; Donadio, Márcio V F ; Nunes, Fernanda B ; de Azambuja, Marcos S ; Santana, João C ; Moraes, Cristina M B ; Mello, Ricardo O ; Cassel, Eduardo ; Pereira, Marcos Aurélio de Almeida ; de Oliveira, Jarbas R
Subjects: Analgesics - isolation & purification ; Analgesics - therapeutic use ; Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - therapeutic use ; antioxidante ; Antioxidants - isolation & purification ; Antioxidants - therapeutic use ; Carrageenan ; Croton Oil ; Disease Models, Animal ; Edema - chemically induced ; Edema - drug therapy ; Female ; inflamação ; lavanda ; MULTIDISCIPLINARY SCIENCES ; nocicepção ; Oils, Volatile - therapeutic use ; Pain - chemically induced ; Pain - drug therapy ; Pain Measurement ; Plant Oils - therapeutic use ; Rats ; Rats, Wistar
Is Part Of: Anais da Academia Brasileira de Ciências, 2015-08, Vol.87 (2 Suppl), p.1397-1408
Description: Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.
Publisher: Brazil: Academia Brasileira de Ciências
Language: English;Portuguese
Identifier: ISSN: 0001-3765
ISSN: 1678-2690
EISSN: 1678-2690
DOI: 10.1590/0001-3765201520150056
PMID: 26247152
Source: IngentaConnect Free/Open Access Journals
SciELO
GFMER Free Medical Journals
MEDLINE
DOAJ Directory of Open Access Journals

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Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ;ISSN: 0001-3765 ;ISSN: 1678-2690 ;EISSN: 1678-2690 ;DOI: 10.1590/0001-3765201520150056 ;PMID: 26247152

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