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S822 Fatigue Improvement Correlates With Reductions in Work Productivity Impairment and Related Indirect Cost in Patients With Crohn’s Disease: Post Hoc Analysis of Phase 3 Rizankizumab Induction Trials

The American journal of gastroenterology, 2022-10, Vol.117 (10S), p.e591-e592 [Peer Reviewed Journal]

2022 by The American College of Gastroenterology ;ISSN: 0002-9270 ;EISSN: 1572-0241 ;DOI: 10.14309/01.ajg.0000859928.45345.30

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  • Title:
    S822 Fatigue Improvement Correlates With Reductions in Work Productivity Impairment and Related Indirect Cost in Patients With Crohn’s Disease: Post Hoc Analysis of Phase 3 Rizankizumab Induction Trials
  • Author: Louis, Edouard ; Panés, Julian ; Ghosh, Subrata ; Siegmund, Britta ; Lee, Wan-Ju ; Deng, Huiwen ; Kligys, Kristina ; Kalabic, Jasmina ; Loftus, Edward V.
  • Subjects: Cost control ; Crohns disease ; Gastroenterology ; Productivity
  • Is Part Of: The American journal of gastroenterology, 2022-10, Vol.117 (10S), p.e591-e592
  • Description: Introduction: Patients with Crohn’s disease (CD) frequently experience fatigue,1 which may reduce quality of life and work productivity, contributing to patient and societal costs. Linear relationship between improvements from BL in FACIT-F and WPAI Overall Work Impairment (OWI) was assessed; results from the regression analyses were used to calculate cost savings based on corresponding WPAI scores and average hourly wages in the US and Europe. Mean change in WPAI Stratified by Mean Change in FACIT-F Scores from Baseline to Week 12 FACIT-F < 2 2≤ FACIT-F < 9 9≤ FACIT-F < 17 FACIT-F ≥17 P-value Work time missed 146 7.5 ± 32.5 133 -0.7 ± 25.6 162 -3.2 ± 30.1 185 -18.4 ± 36.7 < 0.0001 Overall work impairment 146 2.5 ± 27.3 133 -11.0 ± 26.3 162 -20.8 ± 29.2 185 -37.5 ± 31.3 < 0.0001 Impairment while working 130 -1.4 ± 21.9 121 -14.1 ± 22.6 147 -23.3 ± 23.5 160 -35.7 ± 26.1 < 0.0001 Activity impairment 303 -3.0 ± 23.0 310 -13.3 ± 22.5 300 -23.7 ± 23.7 341 -41.9 ± 26.7 < 0.0001 Data are n and mean change ± standard deviation.
  • Publisher: New York: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 0002-9270
    EISSN: 1572-0241
    DOI: 10.14309/01.ajg.0000859928.45345.30
  • Source: AUTh Library subscriptions: ProQuest Central
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