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An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study

Nutrients, 2024-03, Vol.16 (6), p.784 [Peer Reviewed Journal]

COPYRIGHT 2024 MDPI AG ;2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2024 by the authors. 2024 ;ISSN: 2072-6643 ;EISSN: 2072-6643 ;DOI: 10.3390/nu16060784 ;PMID: 38542694

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Title:
An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study
Author: Colletti, Alessandro ; Procchio, Chiara ; Pisano, Mariaelena ; Martelli, Alma ; Pellizzato, Marzia ; Cravotto, Giancarlo
Subjects: analgesic ; Analgesics ; Ananas ; Ananas comosus by-products ; Anti-Inflammatory Agents - therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Arthritis ; bromelain ; Bromelains - therapeutic use ; Clinical trials ; Drug dosages ; Edema ; Edema - drug therapy ; Edema - etiology ; Edema - prevention & control ; Food ; freeze-dried juice ; Fruits ; Functional foods & nutraceuticals ; Humans ; Ibuprofen ; Ibuprofen - therapeutic use ; Inflammation ; ISO standards ; Molar, Third - surgery ; Nonsteroidal anti-inflammatory drugs ; nutraceutical ; Pain ; Pain, Postoperative - drug therapy ; Patient compliance ; Patients ; Quality of Life ; Surgery ; third molar surgery ; Tooth Extraction - adverse effects ; Trismus - drug therapy ; Trismus - etiology ; Trismus - prevention & control
Is Part Of: Nutrients, 2024-03, Vol.16 (6), p.784
Description: A three-arm, randomized, placebo-controlled clinical study was conducted to assess the impact of lyophilized pineapple extract with titrated bromelain (Brome-Inf ) and purified bromelain on pain, swelling, trismus, and quality of life (QoL) following the surgical extraction of the mandibular third molars. Furthermore, this study examined the need for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) by comparing their effects with a placebo group. This study enrolled 42 individuals requiring the extraction of a single mandibular third molar under local anesthesia. The patients were randomly assigned to receive Brome-Inf , purified bromelain, or a placebo orally, initiating treatment on the day of surgery and continuing for the next 7 days. The primary outcome measured was the requirement for NSAIDs in the three groups. Pain, swelling, and trismus were secondary outcome variables, evaluated postoperatively at 1, 3, and 7 days. This study also assessed the comparative efficacy of freeze-dried pineapple extract and single-component bromelain. Ultimately, the placebo group showed a statistically higher need for ibuprofen (from days 1 to 7) at the study's conclusion ( < 0.0001). In addition, reductions in pain and swelling were significantly higher in both the bromelain and pineapple groups ( < 0.0001 for almost all patients, at all intervals) than in the placebo group. The active groups also demonstrated a significant difference in QoL compared to the placebo group ( < 0.001). A non-significant reduction in trismus occurred in the treatment groups compared to the placebo group. Therefore, the administration of pineapple extract titrated in bromelain showed significant analgesic and anti-edema effects in addition to improving QoL in the postoperative period for patients who had undergone mandibular third molar surgery. Moreover, both bromelain and Brome-Inf supplementation reduced the need for ibuprofen to comparable extents, proving that they are good alternatives to NSAIDs in making the postoperative course more comfortable for these patients. A further investigation with larger samples is necessary to assess the pain-relieving and anti-inflammatory impacts of the entire pineapple phytocomplex in surgical procedures aside from mandibular third molar surgery.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 2072-6643
EISSN: 2072-6643
DOI: 10.3390/nu16060784
PMID: 38542694
Source: DOAJ Directory of Open Access Journals
GFMER Free Medical Journals
MEDLINE
PubMed Central
Coronavirus Research Database
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central

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An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study

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