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Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate

The New England journal of medicine, 2016-02, Vol.374 (5), p.411-421 [Peer Reviewed Journal]

Copyright © 2015 Massachusetts Medical Society. All rights reserved. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1510491 ;PMID: 26544982

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Title:
Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate
Author: Grams, Morgan E ; Sang, Yingying ; Levey, Andrew S ; Matsushita, Kunihiro ; Ballew, Shoshana ; Chang, Alex R ; Chow, Eric K.H ; Kasiske, Bertram L ; Kovesdy, Csaba P ; Nadkarni, Girish N ; Shalev, Varda ; Segev, Dorry L ; Coresh, Josef ; Lentine, Krista L ; Garg, Amit X
Subjects: Adult ; Aged ; Blood & organ donations ; Diabetes mellitus ; End-stage renal disease ; Female ; Glomerular Filtration Rate ; Health aspects ; Health risk assessment ; Humans ; Hypertension ; Incidence ; Kidney diseases ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - ethnology ; Kidney Failure, Chronic - surgery ; Kidney Transplantation ; Kidneys ; Living Donors ; Male ; Meta-analysis ; Middle Aged ; Models, Statistical ; Organ donors ; Renal failure ; Risk Assessment - methods ; Risk Factors ; Sex Factors ; Smoking ; Systematic review ; Transplants & implants ; United States - epidemiology
Is Part Of: The New England journal of medicine, 2016-02, Vol.374 (5), p.411-421
Description: This study examined risk associations calibrated to the U.S. population-level incidence of end-stage renal disease and death and projected long-term incidences of ESRD. Risk projections among nondonors were lower than 15-year observed risks after donation. Nearly 30,000 people worldwide become living kidney donors each year. 1 – 3 Traditionally, living donors have been selected on the basis of an absence of risk factors for poor outcomes after donation and without a comprehensive assessment of individualized long-term risk. Although kidney donation is considered to be safe in healthy, low-risk persons, donation has lifelong implications, and the most direct effect may be an increased long-term risk of end-stage renal disease (ESRD). 4 – 7 A tool to predict a donor candidate’s long-term risk of ESRD that incorporates the combined effect of multiple demographic and health characteristics before donation could help make . . .
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1510491
PMID: 26544982
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate

Copyright © 2015 Massachusetts Medical Society. All rights reserved. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1510491 ;PMID: 26544982

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