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Iron uptake and transport across physiological barriers

Biometals, 2016-08, Vol.29 (4), p.573-591 [Peer Reviewed Journal]

The Author(s) 2016 ;Springer Science+Business Media New York 2016 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-016-9952-2 ;PMID: 27457588

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  • Title:
    Iron uptake and transport across physiological barriers
  • Author: Duck, Kari A. ; Connor, James R.
  • Subjects: Animals ; Barriers ; Biochemistry ; Biological Transport ; Biomedical and Life Sciences ; Blood-brain barrier ; Blood-Brain Barrier - metabolism ; Cell Biology ; Humans ; Intestines ; Iron ; Iron - metabolism ; Life Sciences ; Medicine/Public Health ; Microbiology ; Oxygen ; Pharmacology/Toxicology ; Placenta ; Plant Physiology ; Synthesis ; Transport ; Uptakes
  • Is Part Of: Biometals, 2016-08, Vol.29 (4), p.573-591
  • Description: Iron is an essential element for human development. It is a major requirement for cellular processes such as oxygen transport, energy metabolism, neurotransmitter synthesis, and myelin synthesis. Despite its crucial role in these processes, iron in the ferric form can also produce toxic reactive oxygen species. The duality of iron’s function highlights the importance of maintaining a strict balance of iron levels in the body. As a result, organisms have developed elegant mechanisms of iron uptake, transport, and storage. This review will focus on the mechanisms that have evolved at physiological barriers, such as the intestine, the placenta, and the blood–brain barrier (BBB), where iron must be transported. Much has been written about the processes for iron transport across the intestine and the placenta, but less is known about iron transport mechanisms at the BBB. In this review, we compare the established pathways at the intestine and the placenta as well as describe what is currently known about iron transport at the BBB and how brain iron uptake correlates with processes at these other physiological barriers.
  • Publisher: Dordrecht: Springer Netherlands
  • Language: English;Dutch
  • Identifier: ISSN: 0966-0844
    EISSN: 1572-8773
    DOI: 10.1007/s10534-016-9952-2
    PMID: 27457588
  • Source: MEDLINE
    Springer Nature OA/Free Journals
    ProQuest Central
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