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Antibacterial effect of silver nanoparticles on Staphylococcus aureus

Biometals, 2011-02, Vol.24 (1), p.135-141 [Peer Reviewed Journal]

Springer Science+Business Media, LLC. 2010 ;Springer Science+Business Media, LLC. 2010. ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-010-9381-6 ;PMID: 20938718

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Title:
Antibacterial effect of silver nanoparticles on Staphylococcus aureus
Author: Li, Wen-Ru ; Xie, Xiao-Bao ; Shi, Qing-Shan ; Duan, Shun-Shan ; Ouyang, You-Sheng ; Chen, Yi-Ben
Subjects: ABC transporter ; Abundance ; Acetyltransferase ; Acetyltransferases - metabolism ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; ATP-binding protein ; Bacteria ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Wall - drug effects ; Cell walls ; Dehydrogenase ; Dehydrogenases ; Deoxyribonucleic acid ; DNA ; Dose-Response Relationship, Drug ; Electron transport ; Enzymatic activity ; Glycerol ; Glycerol-3-phosphate ; Glycerol-3-phosphate dehydrogenase ; Glycerolphosphate Dehydrogenase - antagonists & inhibitors ; Glycerolphosphate Dehydrogenase - metabolism ; Life Sciences ; Medicine/Public Health ; Metal Nanoparticles - chemistry ; Microbial Sensitivity Tests ; Microbiology ; Nanoparticles ; Oxidoreductases - antagonists & inhibitors ; Oxidoreductases - metabolism ; Pharmacology/Toxicology ; Plant Physiology ; Protein folding ; Protein transport ; Proteins ; Proteomics ; Recombinase ; Recombinases - antagonists & inhibitors ; Recombinases - metabolism ; Silver ; Silver - chemistry ; Silver - pharmacology ; Staphylococcus aureus ; Staphylococcus aureus - cytology ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - enzymology ; Staphylococcus infections ; Transporter
Is Part Of: Biometals, 2011-02, Vol.24 (1), p.135-141
Description: The antibacterial activity and mechanism of silver nanoparticles (Ag-NPs) on Staphylococcus aureus ATCC 6538P were investigated in this study. The experiment results showed the minimum bactericidal concentration (MBC) of Ag-NPs to S. aureus was 20 μg/ml. Moreover, when bacteria cells were exposed to 50 μg/ml Ag-NPs for 6 h, the cell DNA was condensed to a tension state and could have lost their replicating abilities. When S. aureus cells were exposed to 50 μg/ml Ag-NPs for 12 h, the cell wall was breakdown, resulting in the release of the cellular contents into the surrounding environments, and finally became collapsed. And Ag-NPs could reduce the enzymatic activity of respiratory chain dehydrogenase. Furthermore, the proteomic analysis showed that the expression abundance of some proteins was changed in the treated bacterial cell with Ag-NPs, formate acetyltransferase increased 5.3-fold in expression abundance, aerobic glycerol-3-phosphate dehydrogenase decreased 6.5-fold, ABC transporter ATP-binding protein decreased 6.2-fold, and recombinase A protein decreased 4.9-fold.
Publisher: Dordrecht: Springer Netherlands
Language: English;Dutch
Identifier: ISSN: 0966-0844
EISSN: 1572-8773
DOI: 10.1007/s10534-010-9381-6
PMID: 20938718
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Antibacterial effect of silver nanoparticles on Staphylococcus aureus

Springer Science+Business Media, LLC. 2010 ;Springer Science+Business Media, LLC. 2010. ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-010-9381-6 ;PMID: 20938718

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