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Cardiovascular Disease Risk Across a Spectrum of Adverse Plasma Lipid Combinations by Gender and Glycemic Status

The American journal of cardiology, 2019-09, Vol.124 (5), p.702-708 [Peer Reviewed Journal]

2019 ;Copyright © 2019. Published by Elsevier Inc. ;Copyright Elsevier Limited Sep 1, 2019 ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2019.05.058 ;PMID: 31311663

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Title:
Cardiovascular Disease Risk Across a Spectrum of Adverse Plasma Lipid Combinations by Gender and Glycemic Status
Author: Liu, Xiaojuan ; Yang, Yachao ; Kang, Fengling ; Li, Jiqing ; Zhou, Miao ; Ma, Xiaotian ; Yu, Tao ; Zhang, Tao ; Xue, Fuzhong
Subjects: Adjustment ; Adult ; Age Factors ; Aged ; Alcohol ; Blood Glucose ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; China - epidemiology ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cohort Studies ; Comorbidity ; Confidence intervals ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Disease prevention ; Family medical history ; Female ; Gender ; Health risks ; Heart diseases ; High density lipoprotein ; Hospitals ; Humans ; Hypertriglyceridemia - blood ; Hypertriglyceridemia - diagnosis ; Hypertriglyceridemia - epidemiology ; Laboratories ; Lipids ; Longitude ; Longitudinal Studies ; Low density lipoprotein ; Low level ; Male ; Middle Aged ; Population studies ; Prevalence ; Proportional Hazards Models ; Risk analysis ; Risk Assessment ; Risk factors ; Sex Factors ; Statins ; Survival Rate ; Triglycerides
Is Part Of: The American journal of cardiology, 2019-09, Vol.124 (5), p.702-708
Description: High triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) and high non–HDL-C levels are risk factors for cardiovascular disease (CVD). It is unclear whether the combinations of their adverse changes are related with CVD risk in different gender and diabetes status, particularly in Chinese population. This study aims to evaluate the CVD risk associated with different adverse lipid combinations. A total of 38,989 participants from Chinese Multicenter Longitudinal Health Management Cohorts (mean age 42 years; 62% male) without baseline CVD were followed up for incident CVD from 2007 to 2015. Participants with various combinations of baseline TG, non-HDL-C, and HDL-C levels within- or out of range according to Adult Treatment Panel III were grouped into 8 distinct lipid categories. Cox models estimated the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of different lipid categories for CVD. After multivariable adjustment, a low level of HDL-C combined with either a high level of non–HDL-C alone or TG alone were associated with increased CVD risk with adjusted HRs (95% CIs) of 1.77 (1.36 to 2.30) and 2.08 (1.30 to 3.34) in male participants. Diabetic participants with high non–HDL-C and low HDL-C levels (adjusted HR 2.93, 95% CI 1.15 to 7.46), and non-diabetic participants with high TG and low HDL-C levels (adjusted HR 1.73, 95% CI 1.33 to 2.26) had greater risk of incident CVD. These relations remained significant when limited analysis to participants with normal LDL-C levels of <3.4 mmol/L, indicating the various combinations of out-of-range lipid profiles other than LDL-C are associated with different CVD risk and the associations depend on gender and glycemic status.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-9149
EISSN: 1879-1913
DOI: 10.1016/j.amjcard.2019.05.058
PMID: 31311663
Source: MEDLINE
ProQuest Central

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Cardiovascular Disease Risk Across a Spectrum of Adverse Plasma Lipid Combinations by Gender and Glycemic Status

2019 ;Copyright © 2019. Published by Elsevier Inc. ;Copyright Elsevier Limited Sep 1, 2019 ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2019.05.058 ;PMID: 31311663

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