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Relation of Isolated Low High-Density Lipoprotein Cholesterol to Mortality and Cardiorespiratory Fitness (from the Henry Ford Exercise Testing Project [FIT Project])

The American journal of cardiology, 2019-05, Vol.123 (9), p.1429-1434 [Peer Reviewed Journal]

2019 Elsevier Inc. ;Copyright © 2019 Elsevier Inc. All rights reserved. ;2019. Elsevier Inc. ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2019.02.009 ;PMID: 30827489

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Title:
Relation of Isolated Low High-Density Lipoprotein Cholesterol to Mortality and Cardiorespiratory Fitness (from the Henry Ford Exercise Testing Project [FIT Project])
Author: Whelton, Seamus P. ; Dardari, Zeina ; Handy Marshall, Cathy ; Ahmed, Haitham ; Brawner, Clinton A. ; Ehrman, Jonathan K. ; Keteyian, Steven J. ; Mallah, Mouaz Al ; Blaha, Michael J.
Subjects: Age ; Biomarkers - blood ; Blood pressure ; Cardiorespiratory Fitness - physiology ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - mortality ; Cause of Death - trends ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Confidence intervals ; Density ; Diabetes ; Dyspnea ; Exercise ; Exercise Test - methods ; Family medical history ; Female ; Fitness ; Fitness equipment ; Follow-Up Studies ; Health risk assessment ; Heart rate ; High density lipoprotein ; Humans ; Lipids ; Lipoproteins ; Low density lipoprotein ; Male ; Medical records ; Metabolism ; Michigan - epidemiology ; Middle Aged ; Mortality ; Pain ; Patients ; Physical fitness ; Retrospective Studies ; Risk Assessment - methods ; Risk Factors ; Social security ; Survival Rate - trends ; Treadmills ; Triglycerides ; Variance analysis ; Womens health
Is Part Of: The American journal of cardiology, 2019-05, Vol.123 (9), p.1429-1434
Description: Isolated low high-density lipoprotein cholesterol (HDL-C) is associated with lower fitness and increased mortality. Whether the association between isolated low HDL-C and mortality differs by fitness is uncertain. Patients in the Henry Ford ExercIse Testing Project (FIT Project) completed a physician-referred treadmill stress test and those prescribed lipid-lowering medications or with known cardiovascular disease were excluded. Isolated low HDL-C was defined as HDL-C <40 mg/dl for men and <50 mg/dl for women with low-density lipoprotein cholesterol (LDL-C) and triglycerides <100 mg/dl (n = 688). An optimal lipid panel was defined as HDL-C ≥40 mg/dl for men and ≥50 mg/dl for women with LDL-C and triglycerides <100 mg/dl (n = 2,923). Mortality was ascertained through Social Security Death Index linkage. Patients with isolated low HDL-C had a mean age of 48.9 ± 12.9 years and 62.9% were women. Over a mean follow-up of 10.3 ± 5 years, 12.8% of patients with isolated low HDL-C and 8.7% with optimal lipids died. Compared to individuals with optimal lipids, those with isolated low HDL-C who achieved <6 METs had a lower survival (p = 0.02), whereas there was no mortality difference for those who achieved 6 to 10 METs (p = 0.13) or ≥10 METs (p = 0.66). In adjusted Cox models, the mortality hazard for those with isolated low HDL-C compared with optimal lipids was 1.73 (95% confidence interval [CI] 1.18 to 2.54), 1.90 (95% CI 1.19 to 3.04), and 0.97 (95% CI 0.53 to 1.78) for the METS categories of <6, 6 to 10, and ≥10. In conclusion, individuals with isolated low HDL-C fitness significantly improved risk stratification and only those with lower fitness had an increased totality mortality risk.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-9149
EISSN: 1879-1913
DOI: 10.1016/j.amjcard.2019.02.009
PMID: 30827489
Source: MEDLINE
ProQuest Central

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Relation of Isolated Low High-Density Lipoprotein Cholesterol to Mortality and Cardiorespiratory Fitness (from the Henry Ford Exercise Testing Project [FIT Project])

2019 Elsevier Inc. ;Copyright © 2019 Elsevier Inc. All rights reserved. ;2019. Elsevier Inc. ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2019.02.009 ;PMID: 30827489

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