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Neutrophils as emerging therapeutic targets

Nature reviews. Drug discovery, 2020-04, Vol.19 (4), p.253-275 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/s41573-019-0054-z ;PMID: 31969717

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Title:
Neutrophils as emerging therapeutic targets
Author: Németh, Tamás ; Sperandio, Markus ; Mócsai, Attila
Subjects: Animals ; Autoimmune Diseases - immunology ; Bacterial infections ; Congenital diseases ; Cytokines ; Drug targeting ; Drug therapy ; Forecasts and trends ; Health aspects ; Homeostasis ; Humans ; Infections ; Inflammation ; Inflammation - immunology ; Kinases ; Leukocytes - immunology ; Lupus ; Mutation ; Neutropenia ; Neutrophils ; Neutrophils - immunology ; Pathogenesis ; Rheumatoid arthritis ; Trends
Is Part Of: Nature reviews. Drug discovery, 2020-04, Vol.19 (4), p.253-275
Description: Neutrophils are the most abundant circulating leukocytes, being the first line of defence against bacterial and fungal infections. However, neutrophils also contribute to tissue damage during various autoimmune and inflammatory diseases, and play important roles in cancer progression. The intimate but complex involvement of neutrophils in various diseases makes them exciting targets for therapeutic intervention but also necessitates differentiation of beneficial responses from potentially detrimental side effects. A variety of approaches to therapeutically target neutrophils have emerged, including strategies to enhance, inhibit or restore neutrophil function, with several agents entering clinical trials. However, challenges and controversies in the field remain.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1776
EISSN: 1474-1784
DOI: 10.1038/s41573-019-0054-z
PMID: 31969717
Source: AUTh Library subscriptions: ProQuest Central
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Neutrophils as emerging therapeutic targets

COPYRIGHT 2020 Nature Publishing Group ;COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/s41573-019-0054-z ;PMID: 31969717

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