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Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort

Journal of cardiovascular magnetic resonance, 2017-02, Vol.19 (1), p.18-18, Article 18 [Peer Reviewed Journal]

COPYRIGHT 2017 BioMed Central Ltd. ;COPYRIGHT 2017 BioMed Central Ltd. ;The Author(s). 2017 ;ISSN: 1532-429X ;ISSN: 1097-6647 ;EISSN: 1532-429X ;DOI: 10.1186/s12968-017-0327-9 ;PMID: 28178995

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Title:
Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort
Author: Petersen, Steffen E ; Aung, Nay ; Sanghvi, Mihir M ; Zemrak, Filip ; Fung, Kenneth ; Paiva, Jose Miguel ; Francis, Jane M ; Khanji, Mohammed Y ; Lukaschuk, Elena ; Lee, Aaron M ; Carapella, Valentina ; Kim, Young Jin ; Leeson, Paul ; Piechnik, Stefan K ; Neubauer, Stefan
Subjects: Age Factors ; Aged ; Analysis ; Atrial Function, Left ; Atrial Function, Right ; Biological Specimen Banks ; Cardiovascular diseases ; Diagnosis ; Female ; Health aspects ; Heart - diagnostic imaging ; Heart - physiology ; Humans ; Magnetic resonance imaging ; Magnetic Resonance Imaging - standards ; Male ; Middle Aged ; Observer Variation ; Predictive Value of Tests ; Reference Values ; Reproducibility of Results ; Sex Factors ; Stroke Volume ; United Kingdom ; Ventricular Function, Left ; Ventricular Function, Right ; White People
Is Part Of: Journal of cardiovascular magnetic resonance, 2017-02, Vol.19 (1), p.18-18, Article 18
Description: Cardiovascular magnetic resonance (CMR) is the gold standard method for the assessment of cardiac structure and function. Reference ranges permit differentiation between normal and pathological states. To date, this study is the largest to provide CMR specific reference ranges for left ventricular, right ventricular, left atrial and right atrial structure and function derived from truly healthy Caucasian adults aged 45-74. Five thousand sixty-five UK Biobank participants underwent CMR using steady-state free precession imaging at 1.5 Tesla. Manual analysis was performed for all four cardiac chambers. Participants with non-Caucasian ethnicity, known cardiovascular disease and other conditions known to affect cardiac chamber size and function were excluded. Remaining participants formed the healthy reference cohort; reference ranges were calculated and were stratified by gender and age (45-54, 55-64, 65-74). After applying exclusion criteria, 804 (16.2%) participants were available for analysis. Left ventricular (LV) volumes were larger in males compared to females for absolute and indexed values. With advancing age, LV volumes were mostly smaller in both sexes. LV ejection fraction was significantly greater in females compared to males (mean ± standard deviation [SD] of 61 ± 5% vs 58 ± 5%) and remained static with age for both genders. In older age groups, LV mass was lower in men, but remained virtually unchanged in women. LV mass was significantly higher in males compared to females (mean ± SD of 53 ± 9 g/m vs 42 ± 7 g/m ). Right ventricular (RV) volumes were significantly larger in males compared to females for absolute and indexed values and were smaller with advancing age. RV ejection fraction was higher with increasing age in females only. Left atrial (LA) maximal volume and stroke volume were significantly larger in males compared to females for absolute values but not for indexed values. LA ejection fraction was similar for both sexes. Right atrial (RA) maximal volume was significantly larger in males for both absolute and indexed values, while RA ejection fraction was significantly higher in females. We describe age- and sex-specific reference ranges for the left ventricle, right ventricle and atria in the largest validated normal Caucasian population.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1532-429X
ISSN: 1097-6647
EISSN: 1532-429X
DOI: 10.1186/s12968-017-0327-9
PMID: 28178995
Source: Open Access: DOAJ Directory of Open Access Journals
Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
Springer Open Access
MEDLINE

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Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort

COPYRIGHT 2017 BioMed Central Ltd. ;COPYRIGHT 2017 BioMed Central Ltd. ;The Author(s). 2017 ;ISSN: 1532-429X ;ISSN: 1097-6647 ;EISSN: 1532-429X ;DOI: 10.1186/s12968-017-0327-9 ;PMID: 28178995

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