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Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies

International journal of environmental research and public health, 2021-11, Vol.18 (22), p.12022 [Peer Reviewed Journal]

2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 by the authors. 2021 ;ISSN: 1660-4601 ;ISSN: 1661-7827 ;EISSN: 1660-4601 ;DOI: 10.3390/ijerph182212022 ;PMID: 34831779

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  • Title:
    Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies
  • Author: Hohls, Johanna Katharina ; König, Hans-Helmut ; Quirke, Eleanor ; Hajek, André
  • Subjects: Age groups ; Anxiety ; Anxiety disorders ; Bias ; Coronaviruses ; COVID-19 ; Health surveys ; Longitudinal studies ; Medical Subject Headings-MeSH ; Mental depression ; Mental disorders ; Meta-analysis ; Observational studies ; Pandemics ; Quality of life ; Remission ; Reviews ; Statistical methods ; Systematic Review ; Variables
  • Is Part Of: International journal of environmental research and public health, 2021-11, Vol.18 (22), p.12022
  • Description: This review aimed to systematically review observational studies investigating the longitudinal association between anxiety, depression and quality of life (QoL). A systematic search of five electronic databases (PubMed, PsycINFO, PSYNDEX, NHS EED and EconLit) as well as forward/backward reference searches were conducted to identify observational studies on the longitudinal association between anxiety, depression and QoL. Studies were synthesized narratively. Additionally, a random-effects meta-analysis was performed using studies applying the mental and physical summary scores (MCS, PCS) of the Short Form Health Survey. The review was prospectively registered with PROSPERO and a study protocol was published. n = 47 studies on heterogeneous research questions were included, with sample sizes ranging from n = 28 to 43,093. Narrative synthesis indicated that QoL was reduced before disorder onset, dropped further during the disorder and improved with remission. Before onset and after remission, QoL was lower in comparison to healthy comparisons. n = 8 studies were included in random-effects meta-analyses. The pooled estimates of QoL at follow-up (FU) were of small to large effect sizes and showed that QoL at FU differed by disorder status at baseline as well as by disorder course over time. Disorder course groups differed in their MCS scores at baseline. Effect sizes were generally larger for MCS relative to PCS. The results highlight the relevance of preventive measures and treatment. Future research should consider individual QoL domains, individual anxiety/depressive disorders as well as the course of both over time to allow more differentiated statements in a meta-analysis.
  • Publisher: Basel: MDPI AG
  • Language: English
  • Identifier: ISSN: 1660-4601
    ISSN: 1661-7827
    EISSN: 1660-4601
    DOI: 10.3390/ijerph182212022
    PMID: 34831779
  • Source: GFMER Free Medical Journals
    PubMed Central
    Coronavirus Research Database
    ProQuest Central
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