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Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study

Scientific reports, 2018-02, Vol.8 (1), p.3290-11, Article 3290 [Peer Reviewed Journal]

2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2018 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-018-21661-x ;PMID: 29459661

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  • Title:
    Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study
  • Author: Lassale, Camille ; Curtis, Alyscia ; Abete, Itziar ; van der Schouw, Yvonne T ; Verschuren, W M Monique ; Lu, Yunxia ; Bueno-de-Mesquita, H B As
  • Subjects: Arteriosclerosis ; Blood cells ; Blood tests ; Cardiovascular disease ; Cardiovascular diseases ; Erythrocytes ; Health risk assessment ; Medicin och hälsovetenskap ; Monocytes ; Platelets ; Risk factors
  • Is Part Of: Scientific reports, 2018-02, Vol.8 (1), p.3290-11, Article 3290
  • Description: All blood cells (white blood cells [WBC], red blood cells [RBC] and platelets) can play a role in atherosclerosis. Complete blood count (CBC) is widely available in clinical practice but utility as potential risk factors for cardiovascular disease (CVD) is uncertain. Our aim was to assess the associations of pre-diagnostic CBC with incidence of CVD in 14,362 adults free of CVD and aged 47.8 (±11.7) years at baseline, followed-up for 11.4 years (992 incident cases). Cox proportional hazards regressions were used to estimate HRs and 95%CI. Comparing the top (T3) to bottom (T1) tertile, increased total WBC, lymphocyte, monocyte and neutrophil counts were associated with higher CVD risk: 1.31 (1.10; 1.55), 1.20 (1.02; 1.41), 1.21 (1.03; 1.41) and 1.24 (1.05; 1.47), as well as mean corpuscular volume (MCV: 1.23 [1.04; 1.46]) and red cell distribution width (RDW: 1.22 [1.03; 1.44]). Platelets displayed an association for count values above the clinically normal range: 1.49 (1.00; 2.22). To conclude, total and differential WBC count, MCV, RDW and platelet count likely play a role in the aetiology of CVD but only WBC provide a modest improvement for the prediction of 10-year CVD risk over traditional CVD risk factors in a general population.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2045-2322
    EISSN: 2045-2322
    DOI: 10.1038/s41598-018-21661-x
    PMID: 29459661
  • Source: PubMed Central
    SWEPUB Freely available online
    ProQuest Central
    DOAJ Directory of Open Access Journals
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