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Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study

Scientific reports, 2020-10, Vol.10 (1), p.18675, Article 18675 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-020-75633-1 ;PMID: 33122777

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Title:
Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
Author: Bordoni, Laura ; Samulak, Joanna J ; Sawicka, Angelika K ; Pelikant-Malecka, Iwona ; Radulska, Adrianna ; Lewicki, Lukasz ; Kalinowski, Leszek ; Gabbianelli, Rosita ; Olek, Robert A
Subjects: Aged ; Arteriosclerosis ; Biological Transport ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - metabolism ; Case-Control Studies ; Cholesterol ; Cholesterol - metabolism ; Cholesterol Ester Transfer Proteins - blood ; Cholesterol Ester Transfer Proteins - genetics ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cholesteryl ester transfer protein ; Coronary artery ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Haplotypes ; Heart diseases ; Humans ; Macrophages ; Male ; Methylamines - metabolism ; Middle Aged ; Polymorphism, Single Nucleotide ; Trimethylamine
Is Part Of: Scientific reports, 2020-10, Vol.10 (1), p.18675, Article 18675
Description: The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association between TMAO and CETP polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/s41598-020-75633-1
PMID: 33122777
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study

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