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Polygenic Risk Score Use in a Simulated Encounter with a Black vs. White Patient with Obesity

Obesity (Silver Spring, Md.), 2021-12, Vol.29, p.32-32 [Peer Reviewed Journal]

Copyright Blackwell Publishing Ltd. Dec 2021 ;ISSN: 1930-7381 ;EISSN: 1930-739X

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  • Title:
    Polygenic Risk Score Use in a Simulated Encounter with a Black vs. White Patient with Obesity
  • Author: Persky, Susan ; Hollister, Brittany ; Telaak, Sydney ; Dolwick, Alexander ; Schopp, Emma ; Buscetta, Ashley ; Bonham, Vence
  • Subjects: Diabetes ; Health risk assessment ; Medical students ; Obesity
  • Is Part Of: Obesity (Silver Spring, Md.), 2021-12, Vol.29, p.32-32
  • Description: Background: Precision medicine is becoming relevant for common conditions like obesity. In tandem, industry is leveraging emerging genomic technologies to provide risk information directly to consumers. There is increasing interest in the potential for polygenic risk scores (PRS) as all-encompassing metrics of individual risk for obesity and other complex diseases. However, little information exists on how provision of PRS related to these conditions could be used in the clinic. This is particularly important given lack of PRS relevance for patients of non-European ancestry and the controversy with the use of race in clinic practice and medical education. Methods: Third- and fourth-year medical students (N = 81) interacted with a virtual reality-based female patient with obesity. The virtual patient varied as to whether she shared a PRS report indicating increased genetic risk of obesity, type 2 diabetes, and kidney disease. The patient was further randomized as to her apparent race (Black vs. White). Results: Medical students spent more time discussing genetic risk with the White patient (F = 4.20, p < .05). When the Black virtual patient presented with PRS, medical students more often recommended type 2 diabetes assessment in response to fatigue symptoms (x2 = 12.83, p < .01). Measures of stereotyping and bias suggest a crossover interaction in which provision of PRS improved treatment of the White patient but worsened treatment of the Black patient (F = 9.98, p < .01). Conclusions: This work presents preliminary evidence that PRS for obesity and other common, complex diseases may be considered in the care of women with obesity when available, and that it may have variable influences on racial bias and discrimination. Educational interventions may be needed to facilitate appropriate and equitable use of PRS in healthcare.
  • Publisher: Silver Spring: Blackwell Publishing Ltd
  • Language: English
  • Identifier: ISSN: 1930-7381
    EISSN: 1930-739X
  • Source: ProQuest Central
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