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Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations

Hereditas, 2018-04, Vol.155 (1), p.19-19, Article 19 [Peer Reviewed Journal]

The Author(s) 2018 ;ISSN: 1601-5223 ;ISSN: 0018-0661 ;EISSN: 1601-5223 ;DOI: 10.1186/s41065-018-0057-5 ;PMID: 29636655

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  • Title:
    Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations
  • Author: Wang, Yuchen ; Lu, Dongsheng ; Chung, Yeun-Jun ; Xu, Shuhua
  • Subjects: Asians - ethnology ; Asians - genetics ; China ; Gene Flow ; Genetic ancestry ; Genetics, Population ; Genome, Human ; Genotyping Techniques ; Han Chinese ; Humans ; Japan ; Japanese ; Korean ; Phylogeny ; Polymorphism, Single Nucleotide ; Population Density ; Population divergence ; Population structure ; Republic of Korea
  • Is Part Of: Hereditas, 2018-04, Vol.155 (1), p.19-19, Article 19
  • Description: Han Chinese, Japanese and Korean, the three major ethnic groups of East Asia, share many similarities in appearance, language and culture etc., but their genetic relationships, divergence times and subsequent genetic exchanges have not been well studied. We conducted a genome-wide study and evaluated the population structure of 182 Han Chinese, 90 Japanese and 100 Korean individuals, together with the data of 630 individuals representing 8 populations wordwide. Our analyses revealed that Han Chinese, Japanese and Korean populations have distinct genetic makeup and can be well distinguished based on either the genome wide data or a panel of ancestry informative markers (AIMs). Their genetic structure corresponds well to their geographical distributions, indicating geographical isolation played a critical role in driving population differentiation in East Asia. The most recent common ancestor of the three populations was dated back to 3000 ~ 3600 years ago. Our analyses also revealed substantial admixture within the three populations which occurred subsequent to initial splits, and distinct gene introgression from surrounding populations, of which northern ancestral component is dominant. These estimations and findings facilitate to understanding population history and mechanism of human genetic diversity in East Asia, and have implications for both evolutionary and medical studies.
  • Publisher: England: BioMed Central
  • Language: English
  • Identifier: ISSN: 1601-5223
    ISSN: 0018-0661
    EISSN: 1601-5223
    DOI: 10.1186/s41065-018-0057-5
    PMID: 29636655
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    AUTh Library subscriptions: ProQuest Central
    MEDLINE
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