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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

The New England journal of medicine, 2017-07, Vol.377 (2), p.111-121 [Peer Reviewed Journal]

Copyright © 2017 Massachusetts Medical Society. All rights reserved. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1701719 ;PMID: 28636844

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Title:
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
Author: Jaiswal, Siddhartha ; Natarajan, Pradeep ; Silver, Alexander J ; Gibson, Christopher J ; Bick, Alexander G ; Shvartz, Eugenia ; McConkey, Marie ; Gupta, Namrata ; Gabriel, Stacey ; Ardissino, Diego ; Baber, Usman ; Mehran, Roxana ; Fuster, Valentin ; Danesh, John ; Frossard, Philippe ; Saleheen, Danish ; Melander, Olle ; Sukhova, Galina K ; Neuberg, Donna ; Libby, Peter ; Kathiresan, Sekar ; Ebert, Benjamin L
Subjects: Age ; Allografts ; Animals ; Aorta ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - genetics ; Blood cells ; Bone marrow ; Calcification (ectopic) ; Cancer ; Cardiac and Cardiovascular Systems ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; Case-Control Studies ; Causes of ; Clinical Medicine ; Clonal Evolution ; Coronary artery disease ; Coronary Disease - genetics ; Coronary heart disease ; Coronary vessels ; Exome ; Genes ; Genetic Predisposition to Disease ; Genomics ; Heart diseases ; Hematology ; Hematopoiesis ; Hematopoiesis - genetics ; Hematopoietic Stem Cells ; Hemopoiesis ; Humans ; Hypercholesterolemia ; Janus kinase 2 ; Kardiologi ; Klinisk medicin ; Lipoproteins ; Macrophages ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Mice ; Mice, Knockout ; Mutation ; Myocardial infarction ; Peripheral blood ; Risk ; Sequence Analysis, DNA - methods
Is Part Of: The New England journal of medicine, 2017-07, Vol.377 (2), p.111-121
Description: The development of clonal hematopoiesis with increasing age was associated with nearly a doubling in the risk of coronary heart disease, along with an increase in coronary calcifications, possibly due to heightened production of inflammatory markers.
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1701719
PMID: 28636844
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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