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TISIDB: an integrated repository portal for tumor–immune system interactions

Bioinformatics, 2019-10, Vol.35 (20), p.4200-4202 [Peer Reviewed Journal]

The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2019 ;The Author(s) (2019). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. ;ISSN: 1367-4803 ;EISSN: 1460-2059 ;EISSN: 1367-4811 ;DOI: 10.1093/bioinformatics/btz210 ;PMID: 30903160

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  • Title:
    TISIDB: an integrated repository portal for tumor–immune system interactions
  • Author: Ru, Beibei ; Wong, Ching Ngar ; Tong, Yin ; Zhong, Jia Yi ; Zhong, Sophia Shek Wa ; Wu, Wai Chung ; Chu, Ka Chi ; Wong, Choi Yiu ; Lau, Chit Ying ; Chen, Ian ; Chan, Nam Wai ; Zhang, Jiangwen
  • Wren, Jonathan
  • Is Part Of: Bioinformatics, 2019-10, Vol.35 (20), p.4200-4202
  • Description: Abstract Summary The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication. Availability and implementation http://cis.hku.hk/TISIDB Supplementary information Supplementary data are available at Bioinformatics online.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 1367-4803
    EISSN: 1460-2059
    EISSN: 1367-4811
    DOI: 10.1093/bioinformatics/btz210
    PMID: 30903160
  • Source: Journals@Ovid Open Access Journal Collection Rolling
    GFMER Free Medical Journals
    PubMed Central
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