skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Plasma metabolomic and lipidomic alterations associated with COVID-19

National Science Review, 2020-07, Vol.7 (7), p.1157-1168 [Peer Reviewed Journal]

The Author(s) 2020. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. ;2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. 2020 ;ISSN: 2095-5138 ;EISSN: 2053-714X ;DOI: 10.1093/nsr/nwaa086 ;PMID: 34676128

Digital Resources/Online E-Resources

Citations Cited by
  • Title:
    Plasma metabolomic and lipidomic alterations associated with COVID-19
  • Author: Wu, Di ; Shu, Ting ; Yang, Xiaobo ; Song, Jian-Xin ; Zhang, Mingliang ; Yao, Chengye ; Liu, Wen ; Huang, Muhan ; Yu, Yuan ; Yang, Qingyu ; Zhu, Tingju ; Xu, Jiqian ; Mu, Jingfang ; Wang, Yaxin ; Wang, Hong ; Tang, Tang ; Ren, Yujie ; Wu, Yongran ; Lin, Shu-Hai ; Qiu, Yang ; Zhang, Ding-Yu ; Shang, You ; Zhou, Xi
  • Subjects: Special Section: SARS-CoV-2
  • Is Part Of: National Science Review, 2020-07, Vol.7 (7), p.1157-1168
  • Description: The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate (GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with COVID-19. Overall, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19.
  • Publisher: China: Oxford University Press
  • Language: English
  • Identifier: ISSN: 2095-5138
    EISSN: 2053-714X
    DOI: 10.1093/nsr/nwaa086
    PMID: 34676128
  • Source: Coronavirus Research Database
Back to results list
Go to Previous pagePrevious Result  15 NextGo to Next page
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait