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Value of positive myocardial technetium-99m-pyrophosphate scintigraphy in the noninvasive diagnosis of cardiac amyloidosis

The American heart journal, 1982-04, Vol.103 (4), p.468-473 [Peer Reviewed Journal]

1982 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/0002-8703(82)90331-3 ;PMID: 6278906

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Title:
Value of positive myocardial technetium-99m-pyrophosphate scintigraphy in the noninvasive diagnosis of cardiac amyloidosis
Author: Wizenberg, Theodore A. ; Muz, Jaroslaw ; Sohn, Young H. ; Samlowski, Wolfram ; Weissler, Arnold M.
Subjects: Aged ; Amyloidosis - diagnosis ; Amyloidosis - diagnostic imaging ; Amyloidosis - physiopathology ; Cardiomyopathies - diagnosis ; Cardiomyopathies - diagnostic imaging ; Cardiomyopathies - physiopathology ; Diphosphates ; Echocardiography ; Female ; Heart - diagnostic imaging ; Heart - physiopathology ; Humans ; Male ; Middle Aged ; Radionuclide Imaging ; Systole ; Technetium ; Technetium Tc 99m Pyrophosphate
Is Part Of: The American heart journal, 1982-04, Vol.103 (4), p.468-473
Description: Ten consecutive patients with tissue-proven amyloidosis, seven of whom presented with congestive heart failure, were found to exhibit intense diffuse uptake of technetium-99m-pyrophosphate (Tc-99m-PYP) on cardiac radionuclide imaging. The patients exhibited echocardiographic and systolic time interval abnormalities suggesting combined restrictive and congestive cardiomyopathic changes. On M-mode echocardiograms, there was symmetrically increased thickness of the interventricular septum and left ventricular (LV) posterior wall in diastole (10 of 10), decreased fractional shortening of the LV minor axis diameter in systole (eight of nine), and decreased percent thickening of the septum (eight of nine) and LV posterior wall (10 of 10) in systole. Three patients demonstrated enlarged LV end-diastolic diameter. All 10 patients had abnormal PEP LVET and eight had shortened LVETI. When combined with noninvasive tests of LV performance, positive myocardial pyrophosphate (PYP) scanning provides a new and useful adjunct in the diagnosis of amyloid heart disease.
Publisher: United States: Mosby, Inc
Language: English
Identifier: ISSN: 0002-8703
EISSN: 1097-6744
DOI: 10.1016/0002-8703(82)90331-3
PMID: 6278906
Source: MEDLINE
Alma/SFX Local Collection

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Value of positive myocardial technetium-99m-pyrophosphate scintigraphy in the noninvasive diagnosis of cardiac amyloidosis

1982 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/0002-8703(82)90331-3 ;PMID: 6278906

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