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Reproductive health risks associated with occupational exposures to antineoplastic drugs in health care settings: a review of the evidence

Journal of occupational and environmental medicine, 2014-09, Vol.56 (9), p.901 [Peer Reviewed Journal]

EISSN: 1536-5948 ;DOI: 10.1097/JOM.0000000000000249 ;PMID: 25153300

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  • Title:
    Reproductive health risks associated with occupational exposures to antineoplastic drugs in health care settings: a review of the evidence
  • Author: Connor, Thomas H ; Lawson, Christina C ; Polovich, Martha ; McDiarmid, Melissa A
  • Subjects: Antineoplastic Agents - adverse effects ; Female ; Health Facilities ; Health Personnel ; Humans ; Male ; Occupational Exposure - adverse effects ; Reproduction - drug effects ; Reproductive Health
  • Is Part Of: Journal of occupational and environmental medicine, 2014-09, Vol.56 (9), p.901
  • Description: Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs. A structured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed. Although effect sizes varied with study size and population, occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage. Studies of infertility and time to pregnancy also suggested an increased risk for subfertility. Antineoplastic drugs are highly toxic in patients receiving treatment, and adverse reproductive effects have been well documented in these patients. Health care workers with long-term, low-level occupational exposure to these drugs also seem to have an increased risk of adverse reproductive outcomes. Additional precautions to prevent exposure should be considered.
  • Publisher: United States
  • Language: English
  • Identifier: EISSN: 1536-5948
    DOI: 10.1097/JOM.0000000000000249
    PMID: 25153300
  • Source: MEDLINE
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