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Mitochondria mediated cell death in diabetes

Apoptosis (London), 2009-12, Vol.14 (12), p.1405-1423 [Peer Reviewed Journal]

Springer Science+Business Media, LLC 2009 ;ISSN: 1360-8185 ;EISSN: 1573-675X ;DOI: 10.1007/s10495-009-0363-5 ;PMID: 19466549

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Title:
Mitochondria mediated cell death in diabetes
Author: Szabadkai, Gyorgy ; Duchen, Michael R
Subjects: Animals ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell Biology ; Cell Death ; Diabetes and Apoptosis ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - physiopathology ; Humans ; Insulin-Secreting Cells - cytology ; Insulin-Secreting Cells - immunology ; Insulin-Secreting Cells - metabolism ; Mitochondria - immunology ; Mitochondria - metabolism ; Oncology ; Virology
Is Part Of: Apoptosis (London), 2009-12, Vol.14 (12), p.1405-1423
Description: Mitochondrial dysfunction plays a role in the pathogenesis of a wide range of diseases that involve disordered cellular fuel metabolism and survival/death pathways, including neurodegenerative diseases, cancer and diabetes. Cytokine, virus recognition and cellular stress pathways converging on mitochondria cause apoptotic and/or necrotic cell death of β-cells in type-1 diabetes. Moreover, since mitochondria generate crucial metabolic signals for glucose stimulated insulin secretion (GSIS), mitochondrial dysfunction underlies both the functional derangement of GSIS and (over-nutrition) stress-induced apoptotic/necrotic β-cell death, hallmarks of type-2 diabetes. The apparently distinct mechanisms governing β-cell life/death decisions during the development of diabetes provide a remarkable example where remote metabolic, immune and stress signalling meet with mitochondria mediated apoptotic/necrotic death pathways to determine the fate of the β-cell. We summarize the main findings supporting such a pivotal role of mitochondria in β-cell death in the context of current trends in diabetes research.
Publisher: Boston: Boston : Springer US
Language: English
Identifier: ISSN: 1360-8185
EISSN: 1573-675X
DOI: 10.1007/s10495-009-0363-5
PMID: 19466549
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Mitochondria mediated cell death in diabetes

Springer Science+Business Media, LLC 2009 ;ISSN: 1360-8185 ;EISSN: 1573-675X ;DOI: 10.1007/s10495-009-0363-5 ;PMID: 19466549

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