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Bioanalysis of recombinant proteins and antibodies by mass spectrometry

Analyst (London), 2009-05, Vol.134 (5), p.825-834 [Peer Reviewed Journal]

2009 INIST-CNRS ;ISSN: 0003-2654 ;EISSN: 1364-5528 ;DOI: 10.1039/b819706g ;PMID: 19381370 ;CODEN: ANALAO

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Title:
Bioanalysis of recombinant proteins and antibodies by mass spectrometry
Author: EZAN, Eric ; DUBOIS, Mathieu ; BECHER, François
Subjects: Analytical chemistry ; Antibodies - analysis ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, Liquid - methods ; Exact sciences and technology ; Immunoassay ; Mass Spectrometry - methods ; Miscellaneous ; Other chromatographic methods ; Recombinant Proteins - analysis ; Sensitivity and Specificity ; Spectrometric and optical methods
Is Part Of: Analyst (London), 2009-05, Vol.134 (5), p.825-834
Description: In recent years, biotechnologically-derived drugs have been a major focus of research and development in the pharmaceutical industry. Their pharmacokinetics and pharmacokinetic/pharmacodynamic relationships impact every stage of the development process and require their assessment in the circulation in preclinical species and in humans. To this end, immunoassays are a reference, but standardisation remains an issue owing to the restricted pattern of antibody specificity and interference with endogenous components. As an alternative, we report here analytical strategies involving liquid chromatography coupled to mass spectrometry (LC-MS) for the accurate quantification of therapeutic proteins and antibodies in biological fluids.
Publisher: Cambridge: Royal Society of Chemistry
Language: English
Identifier: ISSN: 0003-2654
EISSN: 1364-5528
DOI: 10.1039/b819706g
PMID: 19381370
CODEN: ANALAO
Source: MEDLINE
Alma/SFX Local Collection

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Bioanalysis of recombinant proteins and antibodies by mass spectrometry

2009 INIST-CNRS ;ISSN: 0003-2654 ;EISSN: 1364-5528 ;DOI: 10.1039/b819706g ;PMID: 19381370 ;CODEN: ANALAO

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