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TAFRO Syndrome: A Disease Requiring Immediate Medical Attention

Internal Medicine, 2023/01/01, Vol.62(1), pp.27-32 [Peer Reviewed Journal]

2023 by The Japanese Society of Internal Medicine ;Copyright Japan Science and Technology Agency 2023 ;Copyright © 2023 by The Japanese Society of Internal Medicine ;ISSN: 0918-2918 ;EISSN: 1349-7235 ;DOI: 10.2169/internalmedicine.9622-22 ;PMID: 35598998

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Title:
TAFRO Syndrome: A Disease Requiring Immediate Medical Attention
Author: Masaki, Yasufumi ; Ueda, Yusuke ; Yanagisawa, Hiroto ; Arita, Kotaro ; Sakai, Tomoyuki ; Yamada, Kazunori ; Mizuta, Shuichi ; Fukushima, Toshihiro ; Takai, Kazue ; Aoki, Sadao ; Kawabata, Hiroshi
Subjects: Biopsy ; Castleman Disease - pathology ; Castleman's disease ; cyclosporin A ; Differential diagnosis ; Edema - diagnosis ; Edema - drug therapy ; Edema - etiology ; Fibrosis ; Humans ; idiopathic multicentric Castleman disease ; interleukin-6 ; Internal medicine ; Lymph nodes ; Lymph Nodes - pathology ; Patients ; POEMS syndrome ; Review ; rituximab ; Thrombocytopenia ; Thrombocytopenia - drug therapy ; tocilizumab
Is Part Of: Internal Medicine, 2023/01/01, Vol.62(1), pp.27-32
Description: TAFRO syndrome was first described in 2010, standing for thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly. Because the lymph node histopathology of TAFRO syndrome mimics idiopathic multicentric Castleman disease (iMCD), some researchers consider TAFRO syndrome to be a subtype of iMCD. However, the clinical features of TAFRO syndrome considerably differ from those of iMCD without TAFRO. The clinical features of patients with TAFRO syndrome with or without iMCD-histopathology are similar, and these patients require an accurate diagnosis and urgent treatment. Although a histological diagnosis, including a differential diagnosis, is important, lymph node involvement in patients with TAFRO syndrome is usually modest or sometimes absent. Furthermore, a bleeding tendency due to thrombocytopenia and severe anasarca hampers performing a biopsy. Nonetheless, patients with various other disorders may manifest TAFRO syndrome-like symptoms, making the differential diagnosis in borderline cases difficult. Therefore, the establishment of precise and specific biomarkers is important.
Publisher: Japan: The Japanese Society of Internal Medicine
Language: English
Identifier: ISSN: 0918-2918
EISSN: 1349-7235
DOI: 10.2169/internalmedicine.9622-22
PMID: 35598998
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection

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TAFRO Syndrome: A Disease Requiring Immediate Medical Attention

2023 by The Japanese Society of Internal Medicine ;Copyright Japan Science and Technology Agency 2023 ;Copyright © 2023 by The Japanese Society of Internal Medicine ;ISSN: 0918-2918 ;EISSN: 1349-7235 ;DOI: 10.2169/internalmedicine.9622-22 ;PMID: 35598998

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