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Concentration of acute phase factors in vitreous fluid in diabetic macular edema

Japanese journal of ophthalmology, 2017-11, Vol.61 (6), p.479-483 [Peer Reviewed Journal]

Japanese Ophthalmological Society 2017 ;Japanese Journal of Ophthalmology is a copyright of Springer, 2017. ;ISSN: 0021-5155 ;EISSN: 1613-2246 ;DOI: 10.1007/s10384-017-0525-x ;PMID: 28755024

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Title:
Concentration of acute phase factors in vitreous fluid in diabetic macular edema
Author: Kimura, Kazuhiro ; Orita, Tomoko ; Kobayashi, Yuka ; Matsuyama, Shigeo ; Fujimoto, Kazushi ; Yamauchi, Kazuhiko
Subjects: Acuity ; Acute-Phase Proteins - metabolism ; Aged ; Amyloid ; Biomarkers - metabolism ; C-reactive protein ; Clinical Investigation ; Diabetes ; Diabetes mellitus ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - diagnosis ; Diabetic Retinopathy - metabolism ; Edema ; Female ; Ferritin ; Fibrinogen ; Haptoglobin ; Humans ; Immunoassay ; Macular Edema - diagnosis ; Macular Edema - etiology ; Macular Edema - metabolism ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiplexing ; Ophthalmology ; Optical Coherence Tomography ; Patients ; Procalcitonin ; Retina ; Retina - pathology ; Retrospective Studies ; Surgery ; t-Plasminogen activator ; Tomography, Optical Coherence - methods ; Vascular endothelial growth factor ; Visual Acuity ; Vitreous Body - metabolism
Is Part Of: Japanese journal of ophthalmology, 2017-11, Vol.61 (6), p.479-483
Description: Purpose Diabetic retinal maculopathy is associated with acute and chronic local inflammation. We measured the concentrations of acute phase factors in vitreous fluid of patients with diabetic macular edema (DME) and examined their relations to visual acuity and central retinal thickness (CRT) both before and after vitrectomy. Study design Retrospective. Methods Vitreous fluid was collected during vitreoretinal surgery from 19 patients with DME and 12 control subjects with epiretinal membrane. The concentrations of acute phase factors (α2-macroglobulin, haptoglobin, C-reactive protein, serum amyloid P and A, procalcitonin, ferritin, tissue plasminogen activator, fibrinogen) and vascular endothelial growth factor (VEGF) were measured with multiplex assays. CRT of macular edema was measured by optical coherence tomography (OCT). Results The levels of serum amyloid P, procalcitonin, ferritin, and fibrinogen in vitreous fluid were increased in DME patients compared with control subjects. The levels of procalcitonin and fibrinogen in DME patients were inversely correlated with visual acuity both before and 3 months after vitrectomy but not 6 months postsurgery. The concentrations of these four factors were not correlated with either CRT or the vitreous levels of VEGF in DME patients. Conclusion Acute phase factors may contribute to local inflammation in DME and may therefore influence disease progression.
Publisher: Tokyo: Springer Japan
Language: English
Identifier: ISSN: 0021-5155
EISSN: 1613-2246
DOI: 10.1007/s10384-017-0525-x
PMID: 28755024
Source: MEDLINE
ProQuest Central

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Concentration of acute phase factors in vitreous fluid in diabetic macular edema

Japanese Ophthalmological Society 2017 ;Japanese Journal of Ophthalmology is a copyright of Springer, 2017. ;ISSN: 0021-5155 ;EISSN: 1613-2246 ;DOI: 10.1007/s10384-017-0525-x ;PMID: 28755024

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