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Cerebral Edema Due to Chemotherapeutic Wafer Implantation for Malignant Glioma: Registry Study of Correlation with Perioperative Epileptic Seizures

Neurologia medico-chirurgica, 2022, pp.2021-0398 [Peer Reviewed Journal]

2022 The Japan Neurosurgical Society ;ISSN: 0470-8105 ;EISSN: 1349-8029 ;DOI: 10.2176/jns-nmc.2021-0398

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  • Title:
    Cerebral Edema Due to Chemotherapeutic Wafer Implantation for Malignant Glioma: Registry Study of Correlation with Perioperative Epileptic Seizures
  • Author: FUJII, Yu ; OGIWARA, Toshihiro ; KATO, Hiroto ; HANAOKA, Yoshiki ; HARDIAN, Ridzky Firmansyah ; GOTO, Tetsuya ; HONGO, Kazuhiro ; HORIUCHI, Tetsuyoshi
  • Subjects: BCNU wafer ; cerebral edema ; glioma ; seizure
  • Is Part Of: Neurologia medico-chirurgica, 2022, pp.2021-0398
  • Description: Factors predicting adverse events following implantation with wafers containing 1,3-bis (2-chloroethyl) -1-nitrosourea (carmustine, BCNU), which is used in local chemotherapy for malignant gliomas (MGs), are unknown. The association between cerebral edema (CE), which often occurs after implantation, and perioperative seizures, which are often observed in MG cases, is under debate. This study investigated risk factors for CE associated with BCNU wafer implantation and their relationship with perioperative seizures. A total of 31 surgical cases involving 28 adult patients who underwent BCNU wafer implantation for MGs were investigated and classified into those with and without postoperative transient CE. We assessed the correlations between CE caused by BCNU implantation and various factors, including postoperative epileptic seizures. World Health Organization (WHO) grade III MGs significantly affected postoperative CE (p = 0.003) and the occurrence of seizures (p = 0.0004). Factors predictive of postoperative seizures were WHO grade III MGs (p = 0.0026), increased postoperative CE (p = 0.0272), and history of preoperative seizures (p = 0.0316). Postoperative CE, WHO grade III MGs, and a history of preoperative seizures might predict the postoperative occurrence of seizures, necessitating stringent management of seizures and CE in the affected patients.
  • Publisher: The Japan Neurosurgical Society
  • Language: English
  • Identifier: ISSN: 0470-8105
    EISSN: 1349-8029
    DOI: 10.2176/jns-nmc.2021-0398
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    DOAJ Directory of Open Access Journals
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