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0003 DAT1 GENOTYPE MODULATES THE TIME-ON-TASK EFFECT ON THE PVT DURING TOTAL SLEEP DEPRIVATION

Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A1-A2 [Peer Reviewed Journal]

Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017 ;Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com ;ISSN: 0161-8105 ;EISSN: 1550-9109 ;DOI: 10.1093/sleepj/zsx050.002

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  • Title:
    0003 DAT1 GENOTYPE MODULATES THE TIME-ON-TASK EFFECT ON THE PVT DURING TOTAL SLEEP DEPRIVATION
  • Author: Satterfield, BC ; Wisor, JP ; Schmidt, MA ; Van Dongen, H
  • Subjects: Dopamine ; Genotype & phenotype ; Grants ; Sleep deprivation
  • Is Part Of: Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A1-A2
  • Description: Abstract Introduction: Previous research has shown that the magnitude of the time-on-task (TOT) effect, which is the increase in response variability across the duration of a demanding sustained performance task, is affected by a variable number tandem repeat (VNTR) polymorphism in the Dopamine Transporter SL6CA3 gene (DAT1). Sleep deprivation also induces response variability in such tasks, and amplifies the TOT effect, which suggests shared underlying mechanisms. To explore one possible shared mechanism, we investigated whether DAT1 genotype affects the interaction between the TOT effect and total sleep deprivation (TSD). Methods: 82 healthy adults (27.0 ± 4.7y; 43 females) participated in one of three laboratory studies. Following a baseline period, subjects underwent at least 38h of TSD. A 10-min psychomotor vigilance test (PVT) was administered 12 times throughout the 38h TSD period. For each test bout and each subject, response times were aggregated into 1-min bins. DAT1 was assayed from blood using PCR and visualized by gel electrophoresis. 79 subjects had the 9- or 10-repeat alleles of DAT1. Another 3 subjects had the rare 8- or 11-repeat variants; they were not used for analysis. Results: Mixed-effects ANOVA, controlling for study, showed a significant interaction between 1-min bins and DAT1 genotype (F9,87000=3.07, P=0.001). As observed previously, the TOT effect was reduced in subjects homozygous for the 10-repeat allele. There was also a significant interaction of 1-min bins, time awake, and DAT1 genotype (F99,87000=1.35, P=0.011). Subjects homozygous for the 10-repeat allele showed less amplification of the TOT effect during TSD than subjects with the 9-repeat allele. Conclusion: DAT1 genotype modulates the TOT effect on the PVT during TSD. DAT1 is preferentially expressed in the striatum, where genotype affects DAT1 expression and dopamine availability. This suggests a role for striatal dopamine in shaping the impact of TOT and sleep deprivation on performance as measured with the PVT. Support (If Any): ONR grant N00014-13-1-0302, NIH grants R21CA167691 and R01HL105768, FAA grant DTFAAC-11-A-00003, CDMRP grant W81XWH-16-1-0319.
  • Publisher: US: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0161-8105
    EISSN: 1550-9109
    DOI: 10.1093/sleepj/zsx050.002
  • Source: ProQuest One Psychology
    AUTh Library subscriptions: ProQuest Central
    Alma/SFX Local Collection
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