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0025 ADMIXTURE MAPPING OF SLEEP APNEA PHENOTYPES IN HISPANIC COMMUNITY HEALTH STUDY / STUDY OF LATINOS (HCHS/SOL)

Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A9-A10 [Peer Reviewed Journal]

Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017 ;Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com ;ISSN: 0161-8105 ;EISSN: 1550-9109 ;DOI: 10.1093/sleepj/zsx050.024

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  • Title:
    0025 ADMIXTURE MAPPING OF SLEEP APNEA PHENOTYPES IN HISPANIC COMMUNITY HEALTH STUDY / STUDY OF LATINOS (HCHS/SOL)
  • Author: Wang, H ; Cade, BE ; Saxena, R ; Sofer, T ; Redline, S ; Zhu, X
  • Subjects: Hispanic Americans ; Sleep apnea
  • Is Part Of: Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A9-A10
  • Description: Abstract Introduction: Obstructive Sleep Apnea (OSA) is a common disorder with 20%-40% heritability. Its prevalence and severity vary across ethnic groups. To study the genetic bases of OSA, we applied admixture mapping to identify genetic regions associated with the apnea hypopnea index (AHI) in a large Hispanic/Latino sample, where there is significant variation in ancestral background. Methods: The study included 11,575 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), associated with diverse background groups: Central Americans, Cubans, Dominicans, Mexicans, Puerto Ricans and South Americans. AHI was rank-normal transformed. We tested the association of previously inferred local African, European, and Amerindian ancestry counts with AHI while adjusting for, age, age2, sex, age × sex, BMI, and BMI2. Population stratification and family structure were controlled using 5 principal components, global ancestry, and kinship coefficient matrix in a linear mixed model. The genome-wide significant threshold was 3 × 10–5, after accounting for linkage disequilibrium. Results: The sample has mean age (SD) 46.1 (13.9), mean BMI (SD) 29.8 (6.1), 59 % female, and mean AHI (SD) of 6.4 (12.0). The average local ancestries across study participants were 14.2% (African), 30.9% (Amerindian), and 54.9% (European). We detected one significant region at chromosomes 18: q21 where European ancestry is associated with increasing AHI (p=2.65 × 10–5). Suggestive associations were identified at chromosome 1: p13.3 and chromosome 20: q12 (p<10–3). Conclusion: In this largest admixture mapping study of AHI in Hispanic/Latino Americans, a novel genomic region was identified to harbor OSA related variants. Future association analysis may identify genetic variants that explain sleep apnea susceptibility and its variation across ancestral groups. Support (If Any): This work was supported by NIH/NHLBI R01 HL113338. HCHS/SOL was supported by NHLBI N01-HC65233, N01-HC65234, N01-HC65235 N01-HC65236, N01-HC65237, HHSN268201300005C, NIDCR AM03 and MOD03, NCATS CTSI UL1TR000124, and NIDDK DRC DK063491.
  • Publisher: US: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0161-8105
    EISSN: 1550-9109
    DOI: 10.1093/sleepj/zsx050.024
  • Source: ProQuest One Psychology
    ProQuest Databases
    Alma/SFX Local Collection
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