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Determinants of Human Papillomaviruses (HPVs) positivity in Head and Neck Cancers (HNCs) and Time trends of HPV positivity in Spanish oropharyngeal cancers, using Frequentist and Bayesian approaches

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Title:
Determinants of Human Papillomaviruses (HPVs) positivity in Head and Neck Cancers (HNCs) and Time trends of HPV positivity in Spanish oropharyngeal cancers, using Frequentist and Bayesian approaches
Author: Frias Gomez, Jon
Subjects: 62 Statistics ; 62Q05 Statistical tables ; Bayesian methodology ; Classificació AMS ; Estadística ; Estadística matemàtica ; Head and Neck Cancer (HNC) ; Human Papillomavirus (HPV) ; Log binomial regression ; Logistic regression ; Matemàtiques i estadística ; Prevalence Odds Ratio (POR) ; Statistics-Tables ; Taules ; Time trend analyses ; Àrees temàtiques de la UPC
Description: During the last 15 years, strong evidences have shown that some particular HPVs are involved etiologically in HNCs, especially in the oropharynx. However, this cancer etiology is multifactorial and tobacco and alcohol consumption also play an important role on it. In order to estimate the crude and adjusted HPV prevalence in HNCs, a study, which recruited HNC cases from 1990 to 2012 worldwide using different biological markers, as the presence of the virus DNA, E6*I mRNA, and p16INK4a expression, was conducted at ICO (Castellsagué X., et al., 2016). The aims of this MFP were: 1) To determine the variables associated to HPV infection in HNCs using unconditional logistic regression analysis with in international cross-sectional study. 2) To conduct a time series analysis using Bayesian methodology to evaluate how HPV prevalence in oropharyngeal cancers has evolved from 1990 until 2014 in Spain. 2.1) From a statistical point of view, we compared the results obtained with frequentist statistics to evaluate their benefits and inconveniences.
Publisher: Universitat Politècnica de Catalunya
Creation Date: 2017
Language: English
Source: Recercat

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Determinants of Human Papillomaviruses (HPVs) positivity in Head and Neck Cancers (HNCs) and Time trends of HPV positivity in Spanish oropharyngeal cancers, using Frequentist and Bayesian approaches

info:eu-repo/semantics/openAccess

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